Spontaneous Hematological Remission of Acute Myeloid Leukemia

Overview

Journal Contemp Oncol (Pozn)

Publisher Termedia

Specialty Oncology

Date 2014 May 31

PMID 24876824

Citations 3

Authors

Maciej Kazmierczak

Andrzej Szczepaniak

Anna Czyz

Joanna Rupa-Matysek

Mieczyslaw Komarnicki

Affiliations

Soon will be listed here.

Abstract

Spontaneous remission (SR) of acute myeloid leukemia (AML) in adults is observed very rarely. To date, about 100 cases have been presented in the literature. To our best knowledge, we describe the first adult Polish patient suffering from acute myelomonocytic leukemia (48, XY, +13, +21/46, XY), in whom after supportive therapy, including non-irradiated, non-leukocyte depleted red cell transfusions and low-dose corticosteroid, we observed resolution of the disease without cytogenetic remission. We suggest a potential transfusion-associated graft versus-host-diseases (TA-GVHD) and graft-versus leukemia (GVL) reaction which might lead to spontaneous hematological remission. However, we did not observe clinical symptoms of such reactions apart from a short episode of non-infectious diarrhea. Additionally, steroids were administered but their role in inducing SR, in our opinion, seems less probable. This 77-year-old man remained in SR for 7 months, when repeated analysis showed AML recurrence. He died due to septic shock 2.5 months later. Additionally, we present a review of the literature.

Citing Articles

[A case of spontaneous remission of acute myeloid leukemia with MLL-AF9 rearrangement and abnormal liver function].

Fan W, Xu T, Sang L, Guo J, Li Y, Pei Z Zhonghua Xue Ye Xue Za Zhi. 2021; 42(10):851-857.

PMID: 34788926 PMC: 8607016. DOI: 10.3760/cma.j.issn.0253-2727.2021.10.010.

Spontaneous Remission in a Patient With Acute Myeloid Leukemia Leading to Undetectable Minimal Residual Disease.

Helbig D, Quesada A, Xiao W, Roshal M, Tallman M, Knorr D J Hematol. 2020; 9(1-2):18-22.

PMID: 32362981 PMC: 7188378. DOI: 10.14740/jh606.

The role of TLR8 signaling in acute myeloid leukemia differentiation.

Ignatz-Hoover J, Wang H, Moreton S, Chakrabarti A, Agarwal M, Sun K Leukemia. 2014; 29(4):918-926.

PMID: 25283842 PMC: 4387126. DOI: 10.1038/leu.2014.293.

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