Enigmatic Cassandra: Renal FGF23 Formation in Polycystic Kidney Disease
Overview
Authors
Affiliations
Fibroblast growth factor 23 (FGF23) counteracts phosphate excess and tissue calcification. Phosphate intake, Ca(2+), parathyroid hormone, and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) stimulate FGF23 release from bone. FGF23 inhibits renal 1,25(OH)2D3 formation and phosphate reabsorption. Spichtig and colleagues demonstrate that FGF23 is generated in rodent polycystic kidneys, leading to an increase in plasma FGF23 concentration before reduction in kidney function. FGF23 fails to appreciably downregulate renal phosphate transporter and 1α-25OH-vitamin D hydroxylase activities. Unraveling underlying mechanisms may open diagnostic and therapeutic opportunities.
Mendelian randomization analyses explore the effects of micronutrients on different kidney diseases.
Shi C, Cao H, Zeng G, Wu H, Wang Y Front Nutr. 2024; 11:1440800.
PMID: 39346645 PMC: 11428537. DOI: 10.3389/fnut.2024.1440800.
Perioperative changes of FGF23 in patients undergoing surgery for primary hyperparathyroidism.
Fortova M, Hanouskova L, Valkus M, Cepova J, Prusa R, Kotaska K Endocr Connect. 2021; 11(1).
PMID: 34860179 PMC: 8859952. DOI: 10.1530/EC-21-0430.
Sagar P, Saravanabavan S, Munt A, Wong A, Rangan G J Cardiovasc Dev Dis. 2021; 8(11).
PMID: 34821697 PMC: 8621425. DOI: 10.3390/jcdd8110144.
Elevated FGF23 Levels in Mice Lacking the Thiazide-Sensitive NaCl cotransporter (NCC).
Pathare G, Anderegg M, Albano G, Lang F, Fuster D Sci Rep. 2018; 8(1):3590.
PMID: 29483574 PMC: 5826922. DOI: 10.1038/s41598-018-22041-1.
Multiple faces of fibroblast growth factor-23.
Han X, Quarles L Curr Opin Nephrol Hypertens. 2016; 25(4):333-42.
PMID: 27219044 PMC: 5051268. DOI: 10.1097/MNH.0000000000000240.