Effects of Ischemia on Free Fatty Acids and Diacylglycerols in Developing Rat Brain

Post-decapitative ischemic treatment imposed on the developing rat brain elicited a marked increase in its susceptibility to free fatty acid (FFA) release between 14 and 17 days, an observation similar to that reported by Bazan (Acta Physiol. Lat. Am.21, 15, 1971). Although the level of diacylglycerols (DG) also increased during this period, the extent of the increase was not as obvious as the FFA. Ischemic treatment to rats after 17 days of age elicited increases in DG and FFA enriched in stearic and arachidonic acids. The delayed response in susceptibility of brain tissue to ischemia-induced changes seems to suggest that the biochemical mechanism(s) responsible for the FFA and DG release is better correlated to events commensurating with synaptogenesis than with myelination.