Current Approaches to Enhance CNS Delivery of Drugs Across the Brain Barriers

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2014 May 30

PMID 24872687

Citations 92

Authors

Cui-Tao Lu

Ying-Zheng Zhao

Ho Lun Wong

Jun Cai

Lei Peng

Xin-Qiao Tian

Affiliations

Soon will be listed here.

Abstract

Although many agents have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been clinically used because of the brain barriers. As the protective barrier of the CNS, the blood-brain barrier and the blood-cerebrospinal fluid barrier maintain the brain microenvironment, neuronal activity, and proper functioning of the CNS. Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. The progresses made using these approaches are reviewed, and the associated mechanisms and problems are discussed.

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