Primary Cilia in Pancreatic Development and Disease

Overview

Journal Birth Defects Res C Embryo Today

Date 2014 May 28

PMID 24864023

Citations 29

Authors

Sukanya Lodh

Elizabeth A OHare

Norann A Zaghloul

Affiliations

Soon will be listed here.

Abstract

Primary cilia and their anchoring basal bodies are important regulators of a growing list of signaling pathways. Consequently, dysfunction in proteins associated with these structures results in perturbation of the development and function of a spectrum of tissue and cell types. Here, we review the role of cilia in mediating the development and function of the pancreas. We focus on ciliary regulation of major pathways involved in pancreatic development, including Shh, Wnt, TGF-β, Notch, and fibroblast growth factor. We also discuss pancreatic phenotypes associated with ciliary dysfunction, including pancreatic cysts and defects in glucose homeostasis, and explore the potential role of cilia in such defects.

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