» Articles » PMID: 24863865

Molecular Genetic Studies of ADHD and Its Candidate Genes: a Review

Overview
Journal Psychiatry Res
Specialty Psychiatry
Date 2014 May 28
PMID 24863865
Citations 51
Authors
Affiliations
Soon will be listed here.
Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset psychiatric disorder with high heritability. In recent years, numerous molecular genetic studies have been published to investigate susceptibility loci for ADHD. These results brought valuable candidates for further research, but they also presented great challenge for profound understanding of genetic data and general patterns of current molecular genetic studies of ADHD since they are scattered and heterogeneous. In this review, we presented a retrospective review of more than 300 molecular genetic studies for ADHD from two aspects: (1) the main achievements of various studies were summarized, including linkage studies, candidate-gene association studies, genome-wide association studies and genome-wide copy number variation studies, with a special focus on general patterns of study design and common sample features; (2) candidate genes for ADHD have been systematically evaluated in three ways for better utilization. The thorough summary of the achievements from various studies will provide an overview of the research status of molecular genetics studies for ADHD. Meanwhile, the analysis of general patterns and sample characteristics on the basis of these studies, as well as the integrative review of candidate ADHD genes, will propose new clues and directions for future experiment design.

Citing Articles

Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.

Feng A, Zhi D, Fu Z, Yu S, Luo N, Calhoun V Neurosci Bull. 2025; .

PMID: 39827443 DOI: 10.1007/s12264-025-01349-9.


Assessment of Optical Coherence Tomography Findings in Adults with Attention Deficit Hyperactivity Disorder: A Case-Control Study.

Erdogan E, Hakan Delibas D, Karti O Psychiatry Clin Psychopharmacol. 2024; 31(4):370-378.

PMID: 38765643 PMC: 11079679. DOI: 10.5152/pcp.2021.21183.


Psychological Treatments for Hyperactivity and Impulsivity in Children with ADHD: A Narrative Review.

Sadr-Salek S, Costa A, Steffgen G Children (Basel). 2023; 10(10).

PMID: 37892276 PMC: 10605405. DOI: 10.3390/children10101613.


Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD.

Sveinsdottir H, Christensen C, Borsteinsson H, Lavalou P, Parker M, Shkumatava A Neuropsychopharmacology. 2022; 48(8):1155-1163.

PMID: 36400921 PMC: 10267219. DOI: 10.1038/s41386-022-01505-z.


ADHD diagnosis and methylphenidate consumption in children and adolescents: A systematic analysis of health databases in France over the period 2010-2019.

Ponnou S, Thome B Front Psychiatry. 2022; 13:957242.

PMID: 36299551 PMC: 9590284. DOI: 10.3389/fpsyt.2022.957242.