Look Inside Look AHEAD: Why the Glass is More Than Half-full

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2014 May 28

PMID 24863635

Citations 1

Authors

Helmut Steinberg

Crystal Jacovino

Abbas E Kitabchi

Affiliations

Soon will be listed here.

Abstract

Look AHEAD is the only long-term study in a large cohort of subjects with type 2 diabetes that assessed the effect of intensive lifestyle, predominantly diet and exercise, on a number of outcomes. While Look AHEAD was not able to detect a significant effect of intensive lifestyle modification on cardiovascular outcomes, it clearly demonstrated numerous beneficial and sustained effects on health outcomes that are relevant to this population. Without the exceptional retention of study participants, it would have been difficult to detect these benefits. Our review provides a perspective on aspects related to exercise, diet, and weight loss in relation to cardiovascular outcomes and potential future research.

Citing Articles

Effects of a laboratory-based aerobic exercise intervention on brain volume and cardiovascular health markers: protocol for a randomised clinical trial.

Molina Hidalgo C, Collins A, Crisafio M, Grove G, Kamarck T, Kang C BMJ Open. 2023; 13(11):e077905.

PMID: 37968003 PMC: 10660203. DOI: 10.1136/bmjopen-2023-077905.

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