Novel Product Chemistry from Mechanistic Analysis of Ent-copalyl Diphosphate Synthases from Plant Hormone Biosynthesis

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2014 May 28

PMID 24862907

Citations 35

Authors

Kevin Potter

Jared Criswell

Jiachen Zi

Alisha Stubbs

Reuben J Peters

Affiliations

Soon will be listed here.

Abstract

An active-site water molecule coordinated by conserved histidine and asparagine residues seems to serve as the catalytic base in all ent-copalyl diphosphate synthases (CPSs). When these residues are substituted by alanine, the mutant CPSs produce stereochemically novel ent-8-hydroxy-CPP. Given the requisite presence of CPSs in all land plants for gibberellin phytohormone biosynthesis, such plasticity presumably underlies the observed extensive diversification of the resulting labdane-related diterpenoids.

Citing Articles

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Chen X, Xu M, Han J, Schmidt-Dannert M, Peters R, Chen F Hortic Res. 2024; 11(10):uhae221.

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