Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2014 May 27

PMID 24860551

Citations 63

Authors

Nathalie Castanon

Julie Lasselin

Lucile Capuron

Affiliations

Soon will be listed here.

Abstract

Neuropsychiatric symptoms are frequent in obesity. In addition to their substantial economic and health impact, these symptoms significantly interfere with the quality of life and social function of obese individuals. While the pathophysiological mechanisms underlying obesity-related neuropsychiatric symptoms are still under investigation and remain to be clearly identified, there is increasing evidence for a role of inflammatory processes. Obesity is characterized by a chronic low-grade inflammatory state that is likely to influence neuropsychiatric status given the well-known and highly documented effects of inflammation on brain activity/function and behavior. This hypothesis is supported by recent findings emanating from clinical investigations in obese subjects and from experimentations conducted in animal models of obesity. These studies converge to show that obesity-related inflammatory processes, originating either from the adipose tissue or gut microbiota environment, spread to the brain where they lead to substantial changes in neurocircuitry, neuroendocrine activity, neurotransmitter metabolism and activity, and neurogenesis. Together, these alterations contribute to shape the propitious bases for the development of obesity-related neuropsychiatric comorbidities.

Citing Articles

High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.

de Noronha S, de Moraes L, Hassell Jr J, Stamper C, Arnold M, Heinze J Biol Res. 2024; 57(1):23.

PMID: 38705984 PMC: 11071217. DOI: 10.1186/s40659-024-00505-1.

Human gut microbiome, diet, and mental disorders.

Borrego-Ruiz A, Borrego J Int Microbiol. 2024; 28(1):1-15.

PMID: 38561477 PMC: 11775079. DOI: 10.1007/s10123-024-00518-6.

E-Cigarette Exposure Alters Neuroinflammation Gene and Protein Expression in a Murine Model: Insights from Perinatally Exposed Offspring and Post-Birth Mothers.

Awada C, Saporito A, Zelikoff J, Klein C Genes (Basel). 2024; 15(3).

PMID: 38540381 PMC: 10970539. DOI: 10.3390/genes15030322.

Association between increased BMI and cognitive function in first-episode drug-naïve male schizophrenia.

Deng X, Lu S, Li Y, Fang X, Zhang R, Shen X Front Psychiatry. 2024; 15:1362674.

PMID: 38505798 PMC: 10948420. DOI: 10.3389/fpsyt.2024.1362674.

Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity.

Heisey H, Qualls C, Villareal D, Segoviano-Escobar M, Nava M, Gatchel J J Geriatr Psychiatry Neurol. 2023; 37(4):332-338.

PMID: 37950647 PMC: 11087374. DOI: 10.1177/08919887231215041.

References

Roberts R, Geda Y, Knopman D, Cha R, Boeve B, Ivnik R . Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based study. Alzheimer Dis Assoc Disord. 2009; 24(1):11-8. PMC: 2837096. DOI: 10.1097/WAD.0b013e3181a4485c. View

Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R . Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003; 289(14):1799-804. DOI: 10.1001/jama.289.14.1799. View

Weisberg S, McCann D, Desai M, Rosenbaum M, Leibel R, Ferrante Jr A . Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112(12):1796-808. PMC: 296995. DOI: 10.1172/JCI19246. View

Yates K, Sweat V, Yau P, Turchiano M, Convit A . Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol. 2012; 32(9):2060-7. PMC: 3442257. DOI: 10.1161/ATVBAHA.112.252759. View

Elias M, Elias P, Sullivan L, Wolf P, DAgostino R . Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study. Int J Obes Relat Metab Disord. 2003; 27(2):260-8. DOI: 10.1038/sj.ijo.802225. View

Boitard C, Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A . Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus. 2012; 22(11):2095-100. DOI: 10.1002/hipo.22032. View

Salazar A, Gonzalez-Rivera B, Redus L, Parrott J, OConnor J . Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm Behav. 2012; 62(3):202-9. PMC: 3425718. DOI: 10.1016/j.yhbeh.2012.03.010. View

Hotamisligil G . Inflammation and metabolic disorders. Nature. 2006; 444(7121):860-7. DOI: 10.1038/nature05485. View

Andre C, OConnor J, Kelley K, Lestage J, Dantzer R, Castanon N . Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol. 2008; 200(1-2):90-9. PMC: 2571040. DOI: 10.1016/j.jneuroim.2008.06.011. View

10.

Henry C, Huang Y, Wynne A, Godbout J . Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun. 2008; 23(3):309-17. PMC: 2692986. DOI: 10.1016/j.bbi.2008.09.002. View

11.

Cancello R, Clement K . Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG. 2006; 113(10):1141-7. DOI: 10.1111/j.1471-0528.2006.01004.x. View

12.

Felger J, Miller A . Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012; 33(3):315-27. PMC: 3484236. DOI: 10.1016/j.yfrne.2012.09.003. View

13.

Gibney S, McGuinness B, Prendergast C, Harkin A, Connor T . Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain Behav Immun. 2012; 28:170-81. DOI: 10.1016/j.bbi.2012.11.010. View

14.

Luppino F, de Wit L, Bouvy P, Stijnen T, Cuijpers P, Penninx B . Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010; 67(3):220-9. DOI: 10.1001/archgenpsychiatry.2010.2. View

15.

Aguilar-Valles A, Aguliar-Valles A, Kim J, Jung S, Woodside B, Luheshi G . Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry. 2013; 19(5):599-606. DOI: 10.1038/mp.2013.137. View

16.

Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Laye S . Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav Immun. 2014; 40:9-17. DOI: 10.1016/j.bbi.2014.03.005. View

17.

Raison C, Dantzer R, Kelley K, Lawson M, Woolwine B, Vogt G . CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry. 2009; 15(4):393-403. PMC: 2844942. DOI: 10.1038/mp.2009.116. View

18.

Cani P, Bibiloni R, Knauf C, Waget A, Neyrinck A, Delzenne N . Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008; 57(6):1470-81. DOI: 10.2337/db07-1403. View

19.

Velloso L, Araujo E, De Souza C . Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation. 2008; 15(3):189-93. DOI: 10.1159/000153423. View

20.

Volkow N, Wang G, Baler R . Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci. 2010; 15(1):37-46. PMC: 3124340. DOI: 10.1016/j.tics.2010.11.001. View