Clinical Implications of (epi)genetic Changes in HPV-induced Cervical Precancerous Lesions

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2014 May 24

PMID 24854082

Citations 174

Authors

Renske D M Steenbergen

Peter J F Snijders

Danielle A M Heideman

Chris J L M Meijer

Affiliations

Soon will be listed here.

Abstract

Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of which can overlap. In transforming CIN lesions, aberrations in host cell genes accumulate over time, which is necessary for the ultimate progression to cancer. On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions.

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