Silencing Synapses with DREADDs

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2014 May 24

PMID 24853931

Citations 40

Authors

Hu Zhu

Bryan L Roth

Affiliations

Soon will be listed here.

Abstract

In this issue of Neuron, Stachniak et al. (2014) determine that the chemogenetic silencer hM4Di-DREADD suppresses presynaptic glutamate release, and by generating an axon-targeted hM4Di variant they demonstrate that it can be used to locally silence synaptic transmission in neural circuits.

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