Serum 25-hydroxyvitamin D, Calcium, and Calcium-regulating Hormones in Preeclamptics and Controls During First Day Postpartum

Overview

Journal Endocrine

Specialty Endocrinology

Date 2014 May 24

PMID 24853885

Citations 8

Authors

Ahmed Dalmar

Hershel Raff

Suneet P Chauhan

Maharaj Singh

Danish S Siddiqui

Affiliations

Soon will be listed here.

Abstract

The evidence for a link between vitamin D and preeclampsia is conflicting. There is a paucity of studies reporting simultaneous 25-hydroxyvitamin D (inactive form) and 1,25-dihydroxyvitamin D (biologically active form). We investigated if levels of serum 25-hydroxyvitamin D, calcium-regulating hormones (1,25-dihydroxyvitamin D, parathyroid hormone), and calcium differ significantly between preeclamptics and controls. On postpartum day one, 98 subjects (44 with preeclampsia, 54 controls) were recruited among women admitted to the postdelivery unit, and their serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, serum calcium, and serum albumin levels were prospectively measured. The majority of participants (70%) had serum 25-hydroxyvitamin D level<20 ng/mL; 53% had <15 ng/mL. Mean serum 25-hydroxyvitamin D level was similar between cases and controls (p=0.50). Mean total serum calcium adjusted for albumin and magnesium was similar between cases and controls (p=0.78). Mean serum 1,25-dihydroxyvitamin D and parathyroid hormone levels were normal, and there were no differences between cases and controls. The only significant differences found between preeclamptic cases and controls were mean body mass index, parity, and season of blood draw. Vitamin D levels did not differ among preeclamptic cases and controls.

Citing Articles

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References

Seely E, Brown E, DeMaggio D, Weldon D, Graves S . A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Obstet Gynecol. 1997; 176(1 Pt 1):214-7. DOI: 10.1016/s0002-9378(97)80039-7. View

Cruikshank D, Pitkin R, REYNOLDS W, Williams G, HARGIS G . Effects of magnesium sulfate treatment on perinatal calcium metabolism. I. Maternal and fetal responses. Am J Obstet Gynecol. 1979; 134(3):243-9. DOI: 10.1016/s0002-9378(16)33027-7. View

Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi J . Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011; 7:467-74. PMC: 3148420. DOI: 10.2147/VHRM.S20181. View

Powe C, Evans M, Wenger J, Zonderman A, Berg A, Nalls M . Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013; 369(21):1991-2000. PMC: 4030388. DOI: 10.1056/NEJMoa1306357. View

van den Elzen H, Wladimiroff J, Overbeek T, Morris C, Grobbee D . Calcium metabolism, calcium supplementation and hypertensive disorders of pregnancy. Eur J Obstet Gynecol Reprod Biol. 1995; 59(1):5-16. DOI: 10.1016/0028-2243(94)01992-g. View

Powe C, Seely E, Rana S, Bhan I, Ecker J, Karumanchi S . First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010; 56(4):758-63. PMC: 3775612. DOI: 10.1161/HYPERTENSIONAHA.110.158238. View

Cholst I, Steinberg S, Tropper P, Fox H, Segre G, Bilezikian J . The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med. 1984; 310(19):1221-5. DOI: 10.1056/NEJM198405103101904. View

Schroeder B . ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists. Am Fam Physician. 2002; 66(2):330-1. View

Olson R, Gaylor J, EVERETT M . Skin color, melanin, and erythema. Arch Dermatol. 1973; 108(4):541-4. View

10.

Mulligan M, Felton S, Riek A, Bernal-Mizrachi C . Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2009; 202(5):429.e1-9. PMC: 3540805. DOI: 10.1016/j.ajog.2009.09.002. View

11.

Leu M, Giovannucci E . Vitamin D: epidemiology of cardiovascular risks and events. Best Pract Res Clin Endocrinol Metab. 2011; 25(4):633-46. DOI: 10.1016/j.beem.2011.04.001. View

12.

PAYNE R, Carver M, MORGAN D . Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol. 1979; 32(1):56-60. PMC: 1145568. DOI: 10.1136/jcp.32.1.56. View

13.

Bushinsky D, Monk R . Electrolyte quintet: Calcium. Lancet. 1998; 352(9124):306-11. DOI: 10.1016/s0140-6736(97)12331-5. View

14.

LEVINE R, Hauth J, Curet L, Sibai B, Catalano P, Morris C . Trial of calcium to prevent preeclampsia. N Engl J Med. 1997; 337(2):69-76. DOI: 10.1056/NEJM199707103370201. View

15.

Seely E . Calciotropic hormones in preeclampsia: a renewal of interest. J Clin Endocrinol Metab. 2007; 92(9):3402-3. DOI: 10.1210/jc.2007-1554. View

16.

Granger J, Alexander B, Llinas M, Bennett W, Khalil R . Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation. 2002; 9(3):147-60. DOI: 10.1038/sj.mn.7800137. View

17.

Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaillzadeh A . Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2013; 98(8):3165-73. DOI: 10.1210/jc.2013-1257. View

18.

Gojnic M, Petkovic S, Papic M, Mostic T, Jeremic K, Vilendecic Z . Plasma albumin level as an indicator of severity of preeclampsia. Clin Exp Obstet Gynecol. 2004; 31(3):209-10. View

19.

Thacher T, Clarke B . Vitamin D insufficiency. Mayo Clin Proc. 2011; 86(1):50-60. PMC: 3012634. DOI: 10.4065/mcp.2010.0567. View

20.

Liu S, Tang W, Zhou J, Stubbs J, Luo Q, Pi M . Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol. 2006; 17(5):1305-15. DOI: 10.1681/ASN.2005111185. View