SSRIs Increase Risk of Blood Transfusion in Patients Admitted for Hip Surgery

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 May 23

PMID 24848000

Citations 7

Authors

Hermien Janneke Schutte

Sofie Jansen

Matthias U Schafroth

J Carel Goslings

Nathalie Van der Velde

Sophia E J A de Rooij

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have shown that an increased bleeding tendency can be caused by Selective Serotonin Reuptake Inhibitors (SSRI) use. We aimed to investigate the occurrence and risk of blood transfusion in SSRI users compared to non-SSRI users in a cohort of patients admitted for hip-surgery.

Methods: We conducted a retrospective cohort study of patients who underwent planned or emergency hip surgery from 1996 to 2011 in the Academic Medical Center in Amsterdam. Primary outcome measure was risk of blood transfusion. Secondary outcome measures were pre- and postoperative hemoglobin level. Multivariate logistic regression was used to adjust for potential confounders.

Results: One-hundred and fourteen SSRI users were compared to 1773 non-SSRI users. Risk of blood transfusion during admission was increased for SSRI users in multivariate analyses (OR 1.7 [95% CI 1.1-2.5]). Also, pre-operative hemoglobin levels were lower in SSRI users (7.8 ± 1.0 mmol/L) compared to non-SSRI users (8.0 ± 1.0 mmol/L) (p = 0.042)), as were postoperative hemoglobin levels (6.2 ± 1.0 mmol/L vs. 6.4 ± 1.0 mmol/L respectively) (p = 0.017)).

Conclusions: SSRI users undergoing hip surgery have an increased risk for blood transfusion during admission, potentially explained by a lower hemoglobin level before surgery. SSRI use should be considered as a potential risk indicator for increased blood loss in patients admitted for hip surgery. These results need to be confirmed in a prospective study.

Citing Articles

Association between selective serotonin reuptake inhibitors use and blood transfusion risk in older adults after hip fracture: a cohort study.

Gobillot-Morisson H, Genet B, Frere C, Cohen-Bittan J, Raux M, Rollet M BMC Geriatr. 2024; 24(1):1048.

PMID: 39736543 PMC: 11686848. DOI: 10.1186/s12877-024-05634-6.

Preoperative SSRI use increases perioperative transfusion need in patients undergoing surgical procedures on the hip joint.

Hoveidaei A, Ghaseminejad-Raeini A, Fallahi M, Habibzadeh A, Khonji M, Nwankwo B Eur J Orthop Surg Traumatol. 2024; 34(8):3903-3908.

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A matched-control study on the effects of depressive disorders following open reduction and internal fixation for acetabular fractures.

Ciminero M, Swiggett S, Golub I, Ashraf A, Vakharia R, Kang K Eur J Orthop Surg Traumatol. 2021; 32(6):1105-1110.

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Serotonin reuptake inhibitors and bleeding risks related to elderly submitted to major orthopedic surgery.

Savioli F Einstein (Sao Paulo). 2019; 17(4):eED5214.

PMID: 31618290 PMC: 6777648. DOI: 10.31744/einstein_journal/2019ED5214.

Gunaydin B, Kurtipek O Turk J Anaesthesiol Reanim. 2019; 47(3):244-272.

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