Association Between Serum Adipocytokine Levels and Microangiopathies in Patients with Type 2 Diabetes Mellitus

Overview

Journal J Diabetes Investig

Specialty Endocrinology

Date 2014 May 21

PMID 24843783

Citations 25

Authors

Chan-Hee Jung

Bo-Yeon Kim

Ji-Oh Mok

Sung-Koo Kang

Chul-Hee Kim

Affiliations

Soon will be listed here.

Abstract

Aims/introduction: It is thought that adipocytokines contribute to the increased risk of vascular complications in type 2 diabetes. However, there is still limited information on the relationship between microangiopathies and adipocytokines, such as adiponectin, leptin and tumor necrosis factor-α (TNF-α) in patients with type 2 diabetes.

Materials And Methods: The present study examined the relationship between fasting serum adiponectin, leptin, and TNF-α levels and microangiopathies in Korean type 2 diabetes. A total of 153 patients were recruited and evaluated for diabetic nephropathy, retinopathy and neuropathy. Serum adiponectin, TNF-α and leptin levels were measured.

Results: Serum adiponectin levels were significantly lower in patients with nephropathy than in those without nephropathy (P = 0.017), and were significantly higher in patients with retinopathy or neuropathy than those without retinopathy or neuropathy (P = 0.01 and P = 0.002, respectively). The mean levels of leptin were significantly higher in patients with neuropathy than in those without neuropathy (P = 0.002). The mean levels of TNF-α were not significantly different according to any of the three microangiopathies. Multivariate logistic regression analysis showed that the odds ratio for the presence of neuropathy in the highest tertile of adiponectin was 4.3 (95% confidence interval 1.59-11.62), as compared with the patients in the lowest tertile of adiponectin level.

Conclusions: Levels of adipocytokines were significantly different according to the presence of each microangiopathy. In particular, higher serum adiponectin was independently associated with increased odds for the presence of neuropathy. Future prospective studies with larger numbers of patients are required to establish a direct relationship between plasma adipocytokine concentrations and the development or severity of diabetic microangiopathies.

Citing Articles

Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity.

Molnar A, Szentpeteri A, Lorincz H, Seres I, Harangi M, Balogh Z Rev Cardiovasc Med. 2024; 23(5):160.

PMID: 39077619 PMC: 11273855. DOI: 10.31083/j.rcm2305160.

The Complex Immunological Alterations in Patients with Type 2 Diabetes Mellitus on Hemodialysis.

Trandafir M, Savu O, Gheorghiu M J Clin Med. 2024; 13(13).

PMID: 38999253 PMC: 11242658. DOI: 10.3390/jcm13133687.

Influence of Adipokines on Metabolic Dysfunction and Aging.

Park S, Shimokawa I Biomedicines. 2024; 12(4).

PMID: 38672227 PMC: 11048512. DOI: 10.3390/biomedicines12040873.

Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease.

Hussein M, Saif A, Amin M, Khalafallah O, Hussien A, Aboulsoud S J Nutr Metab. 2023; 2023:6661585.

PMID: 37692464 PMC: 10484655. DOI: 10.1155/2023/6661585.

Integrative analysis of Mendelian randomization and gene expression profiles reveals a null causal relationship between adiponectin and diabetic retinopathy.

Zhang A, Wu H, Wang C, Tian S Adipocyte. 2023; 12(1):2234522.

PMID: 37459460 PMC: 10353325. DOI: 10.1080/21623945.2023.2234522.

References

Looker H, Krakoff J, Funahashi T, Matsuzawa Y, Tanaka S, Nelson R . Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab. 2004; 89(8):4010-7. DOI: 10.1210/jc.2003-031916. View

Zorena K, Mysliwska J, Mysliwiec M, Balcerska A, Hak L, Lipowski P . Serum TNF-alpha level predicts nonproliferative diabetic retinopathy in children. Mediators Inflamm. 2007; 2007:92196. PMC: 1906713. DOI: 10.1155/2007/92196. View

Hosokawa Y, Yamada Y, Obata Y, Baden M, Saisho K, Ihara A . Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients. Clin Exp Nephrol. 2011; 16(3):399-405. DOI: 10.1007/s10157-011-0571-5. View

Kato K, Osawa H, Ochi M, Kusunoki Y, Ebisui O, Ohno K . Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy. Clin Endocrinol (Oxf). 2007; 68(3):442-9. DOI: 10.1111/j.1365-2265.2007.03063.x. View

Flyvbjerg A . Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. Nat Rev Endocrinol. 2010; 6(2):94-101. DOI: 10.1038/nrendo.2009.266. View

Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N . Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem. 2002; 277(40):37487-91. DOI: 10.1074/jbc.M206083200. View

Hasegawa G, Nakano K, Sawada M, Uno K, Shibayama Y, Ienaga K . Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy. Kidney Int. 1991; 40(6):1007-12. DOI: 10.1038/ki.1991.308. View

Asakawa H, Tokunaga K, Kawakami F . Relationship of leptin level with metabolic disorders and hypertension in Japanese type 2 diabetes mellitus patients. J Diabetes Complications. 2001; 15(2):57-62. DOI: 10.1016/s1056-8727(00)00145-8. View

Jung C, Rhee E, Choi J, Bae J, Yoo S, Kim W . The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults. Korean Diabetes J. 2010; 34(4):237-43. PMC: 2932893. DOI: 10.4093/kdj.2010.34.4.237. View

10.

Kern W, Beyer J, Forst T, Pfutzner A, Peters A . Elevated serum leptin concentrations in type 2 diabetic patients with microalbuminuria and macroalbuminuria. Metabolism. 1999; 48(10):1290-3. DOI: 10.1016/s0026-0495(99)90270-6. View

11.

Navarro J, Mora C, Maca M, Garca J . Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. Am J Kidney Dis. 2003; 42(1):53-61. DOI: 10.1016/s0272-6386(03)00408-6. View

12.

Feldman E, Stevens M, Thomas P, Brown M, Canal N, Greene D . A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care. 1994; 17(11):1281-9. DOI: 10.2337/diacare.17.11.1281. View

13.

Sari R, Balci M, Apaydin C . The relationship between plasma leptin levels and chronic complication in patients with type 2 diabetes mellitus. Metab Syndr Relat Disord. 2010; 8(6):499-503. DOI: 10.1089/met.2009.0127. View

14.

Mariano F, Bussolati B, Piccoli G, Camussi G . Renal vascular effects of cytokines. Blood Purif. 1997; 15(4-6):262-72. DOI: 10.1159/000170344. View

15.

Ran J, Xiong X, Liu W, Guo S, Li Q, Zhang R . Increased plasma adiponectin closely associates with vascular endothelial dysfunction in type 2 diabetic patients with diabetic nephropathy. Diabetes Res Clin Pract. 2010; 88(2):177-83. DOI: 10.1016/j.diabres.2010.01.021. View

16.

Meier U, Gressner A . Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004; 50(9):1511-25. DOI: 10.1373/clinchem.2004.032482. View

17.

Saito T, Saito O, Kawano T, Tamemoto H, Kusano E, Kawakami M . Elevation of serum adiponectin and CD146 levels in diabetic nephropathy. Diabetes Res Clin Pract. 2007; 78(1):85-92. DOI: 10.1016/j.diabres.2007.02.014. View

18.

Bajaj M, Suraamornkul S, Piper P, Hardies L, Glass L, Cersosimo E . Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients. J Clin Endocrinol Metab. 2004; 89(1):200-6. DOI: 10.1210/jc.2003-031315. View

19.

Zhang W, Liu H, Al-Shabrawey M, Caldwell R, Caldwell R . Inflammation and diabetic retinal microvascular complications. J Cardiovasc Dis Res. 2011; 2(2):96-103. PMC: 3144626. DOI: 10.4103/0975-3583.83035. View

20.

Imagawa A, Funahashi T, Nakamura T, Moriwaki M, Tanaka S, Nishizawa H . Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes. Diabetes Care. 2002; 25(9):1665-6. DOI: 10.2337/diacare.25.9.1665. View