Natural Antisense Transcripts

Overview

Journal Hum Mol Genet

Specialties Genetics
Molecular Biology

Date 2014 May 20

PMID 24838284

Citations 79

Authors

Olga Khorkova

Amanda J Myers

Jane Hsiao

Claes Wahlestedt

Affiliations

Soon will be listed here.

Abstract

Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously thought to be 'junk DNA'. Roughly defined as non-coding regulatory RNA transcribed from the opposite strand of a coding gene locus, NATs are proving to be a heterogeneous group with high potential for therapeutic application. Here, we attempt to summarize the rapidly growing knowledge about this important non-coding RNA subclass.

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