Reply to Pauls Et Al.: P21 is a Master Regulator of HIV Replication in Macrophages Through DNTP Synthesis Block

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2014 May 17

PMID 24834497

Citations 8

Authors

Awatef Allouch

Annie David

Sarah M Amie

Hichem Lahouassa

Loic Chartier

Florence Margottin-Goguet

Francoise Barre-Sinoussi

Baek Kim

Asier Saez-Cirion

Gianfranco Pancino

Affiliations

Soon will be listed here.

Citing Articles

The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication.

Lin C, Kuffour E, Li T, Gertzen C, Kaiser J, Luedde T Viruses. 2024; 16(4).

PMID: 38675828 PMC: 11053637. DOI: 10.3390/v16040485.

CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia.

Allouch A, Voisin L, Zhang Y, Raza S, Lecluse Y, Calvo J Nat Commun. 2022; 13(1):6739.

PMID: 36347876 PMC: 9643439. DOI: 10.1038/s41467-022-34548-3.

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

Kuffour E, Schott K, Vasudevan A, Holler J, Schulz W, Lang P J Virol. 2018; 92(20).

PMID: 30068654 PMC: 6158439. DOI: 10.1128/JVI.00592-18.

Inhibition of HIV early replication by the p53 and its downstream gene p21.

Shi B, Sharifi H, DiGrigoli S, Kinnetz M, Mellon K, Hu W Virol J. 2018; 15(1):53.

PMID: 29587790 PMC: 5870690. DOI: 10.1186/s12985-018-0959-x.

HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication.

Herskovitz J, Gendelman H J Neuroimmune Pharmacol. 2018; 14(1):52-67.

PMID: 29572681 PMC: 6501843. DOI: 10.1007/s11481-018-9785-6.

References

White T, Brandariz-Nunez A, Valle-Casuso J, Amie S, Nguyen L, Kim B . The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe. 2013; 13(4):441-51. PMC: 3864637. DOI: 10.1016/j.chom.2013.03.005. View

Pauls E, Ruiz A, Riveira-Munoz E, Permanyer M, Badia R, Clotet B . p21 regulates the HIV-1 restriction factor SAMHD1. Proc Natl Acad Sci U S A. 2014; 111(14):E1322-4. PMC: 3986173. DOI: 10.1073/pnas.1322059111. View

Cribier A, Descours B, Chaves Valadao A, Laguette N, Benkirane M . Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep. 2013; 3(4):1036-43. DOI: 10.1016/j.celrep.2013.03.017. View

Bergamaschi A, David A, Le Rouzic E, Nisole S, Barre-Sinoussi F, Pancino G . The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages. J Virol. 2009; 83(23):12253-65. PMC: 2786717. DOI: 10.1128/JVI.01395-09. View

Welbourn S, Dutta S, John Semmes O, Strebel K . Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol. 2013; 87(21):11516-24. PMC: 3807338. DOI: 10.1128/JVI.01642-13. View