Geographic Trends and Risk of Gastrointestinal Cancer Among Patients with Celiac Disease in Europe and Asian-Pacific Region

Overview

Journal Gastroenterol Hepatol Bed Bench

Specialty Gastroenterology

Date 2014 May 17

PMID 24834268

Citations 11

Authors

Mohammad Rostami Nejad

David Aldulaimi

Sauid Ishaq

Mohammad Javad Ehsani-Ardakani

Mohammad Reza Zali

Reza Malekzadeh

Kamran Rostami

Affiliations

Soon will be listed here.

Abstract

Celiac disease is an autoimmune disorder that affects genetically predisposed individuals upon the ingestion of gluten. It is now considered one of the most common genetic disorders in Europe and Asian Pacific region with a prevalence of up to 2.67% of the population. The true prevalence of celiac disease may still be underestimated. Studies remain limited by sample size and selection bias. Celiac disease predisposes to the development of gastrointestinal malignancies, especially lymphomas and small bowel adenocarcinoma. The risk of developing a celiac disease associated malignancies remains uncertain, despite numerous studies. In Middle Eastern countries, the literature regarding celiac disease has expanded significantly in recent years. These studies reported have largely concentrated on the epidemiology of Celiac disease and there is an absolute and relative paucity of published research regarding celiac disease associated malignancy. The aim of this article is to review the current literature and evaluate the risk of gastrointestinal malignancies among patients with celiac disease and then review studies from the Asian Pacific region of the world.

Citing Articles

Inflammation-Associated Stem Cells in Gastrointestinal Cancers: Their Utility as Prognostic Biomarkers and Therapeutic Targets.

Kumari B, Tiwari A, Meena S, Ahirwar D Cancers (Basel). 2024; 16(18).

PMID: 39335106 PMC: 11429849. DOI: 10.3390/cancers16183134.

Prevalence of malignant neoplasms in celiac disease patients - a nationwide United States population-based study.

Haider M, Al Sbihi A, Reddy S, Green P World J Clin Oncol. 2024; 15(8):1048-1060.

PMID: 39193153 PMC: 11346075. DOI: 10.5306/wjco.v15.i8.1048.

Gastric perforation secondary to T-cell lymphoma.

Fernandez-Alberti J, Irribarra M, Rancati A, Panzardi N, Cora M, Speisky D Ecancermedicalscience. 2023; 17:1498.

PMID: 36816790 PMC: 9937071. DOI: 10.3332/ecancer.2023.1498.

Alpha-enolase involvement in intestinal and extraintestinal manifestations of celiac disease.

Lerner A, Sobolevskaia P, Churilov L, Shoenfeld Y J Transl Autoimmun. 2021; 4:100109.

PMID: 34189450 PMC: 8219987. DOI: 10.1016/j.jtauto.2021.100109.

The effect of education on the knowledge of patients with celiac disease.

Barzegar F, Rostami-Nejad M, Mohaghegh Shalmani H, Sadeghi A, Allahverdi Khani M, Aldulaimi D Gastroenterol Hepatol Bed Bench. 2018; 10(Suppl1):S15-S19.

PMID: 29511466 PMC: 5838175.

References

Selby W, GALLAGHER N . Malignancy in a 19-year experience of adult celiac disease. Dig Dis Sci. 1979; 24(9):684-8. DOI: 10.1007/BF01314465. View

Howdle P, Jalal P, Holmes G, Houlston R . Primary small-bowel malignancy in the UK and its association with coeliac disease. QJM. 2003; 96(5):345-53. DOI: 10.1093/qjmed/hcg058. View

Card T, West J, Holmes G . Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study. Aliment Pharmacol Ther. 2004; 20(7):769-75. DOI: 10.1111/j.1365-2036.2004.02177.x. View

Swinson C, Slavin G, Coles E, Booth C . Coeliac disease and malignancy. Lancet. 1983; 1(8316):111-5. DOI: 10.1016/s0140-6736(83)91754-3. View

Schweizer J, Oren A, Mearin M . Cancer in children with celiac disease: a survey of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2001; 33(1):97-100. DOI: 10.1097/00005176-200107000-00020. View

Solaymani-Dodaran M, West J, Logan R . Long-term mortality in people with celiac disease diagnosed in childhood compared with adulthood: a population-based cohort study. Am J Gastroenterol. 2007; 102(4):864-70. DOI: 10.1111/j.1572-0241.2007.01111.x. View

Pan S, Morrison H . Epidemiology of cancer of the small intestine. World J Gastrointest Oncol. 2011; 3(3):33-42. PMC: 3069308. DOI: 10.4251/wjgo.v3.i3.33. View

Elli L, Contiero P, Tagliabue G, Tomba C, Bardella M . Risk of intestinal lymphoma in undiagnosed coeliac disease: results from a registered population with different coeliac disease prevalence. Dig Liver Dis. 2012; 44(9):743-7. DOI: 10.1016/j.dld.2012.04.020. View

Gao Y, Kristinsson S, Goldin L, Bjorkholm M, Caporaso N, Landgren O . Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association. Gastroenterology. 2008; 136(1):91-8. PMC: 3227529. DOI: 10.1053/j.gastro.2008.09.031. View

10.

Smedby K, Baecklund E, Askling J . Malignant lymphomas in autoimmunity and inflammation: a review of risks, risk factors, and lymphoma characteristics. Cancer Epidemiol Biomarkers Prev. 2006; 15(11):2069-77. DOI: 10.1158/1055-9965.EPI-06-0300. View

11.

Ludvigsson J, West J, Ekbom A, Stephansson O . Reduced risk of breast, endometrial and ovarian cancer in women with celiac disease. Int J Cancer. 2011; 131(3):E244-50. DOI: 10.1002/ijc.26454. View

12.

Makishima H, Komiyama Y, Asano N, Momose K, Nakamura S, Ishida F . Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease. Intern Med. 2008; 47(4):295-8. DOI: 10.2169/internalmedicine.47.0500. View

13.

Goldacre M, Wotton C, Yeates D, Seagroatt V, Jewell D . Cancer in patients with ulcerative colitis, Crohn's disease and coeliac disease: record linkage study. Eur J Gastroenterol Hepatol. 2008; 20(4):297-304. DOI: 10.1097/MEG.0b013e3282f2a5e2. View

14.

Peters U, Askling J, Gridley G, Ekbom A, Linet M . Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med. 2003; 163(13):1566-72. DOI: 10.1001/archinte.163.13.1566. View

15.

Fasano A, Berti I, Gerarduzzi T, Not T, Colletti R, Drago S . Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003; 163(3):286-92. DOI: 10.1001/archinte.163.3.286. View

16.

Delco F, El-Serag H, Sonnenberg A . Celiac sprue among US military veterans: associated disorders and clinical manifestations. Dig Dis Sci. 1999; 44(5):966-72. DOI: 10.1023/a:1026660614372. View

17.

Rajabalinia H, Dabiri R, Shahbazi S, Ghobakhlou M, Bahreiny R, Molaei M . Duodenal adenocarcinoma might be the cause of intractable nausea and vomiting in patient with coeliac disease. Gastroenterol Hepatol Bed Bench. 2014; 5(4):209-12. PMC: 4017469. View

18.

Ludvigsson J, Montgomery S, Ekbom A, Brandt L, Granath F . Small-intestinal histopathology and mortality risk in celiac disease. JAMA. 2009; 302(11):1171-8. DOI: 10.1001/jama.2009.1320. View

19.

Silano M, Volta U, De Vincenzi A, Dessi M, De Vincenzi M . Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. Dig Dis Sci. 2007; 53(4):972-6. DOI: 10.1007/s10620-007-9952-8. View

20.

Green PHR , Stavropoulos S, Panagi S, Goldstein S, McMahon D, Absan H . Characteristics of adult celiac disease in the USA: results of a national survey. Am J Gastroenterol. 2001; 96(1):126-31. DOI: 10.1111/j.1572-0241.2001.03462.x. View