Generation of Superoxide Anion Radicals and Platelet Glutathione Peroxidase Activity in Patients with Schizophrenia

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2014 May 17

PMID 24833903

Citations 10

Authors

Anna Dietrich-Muszalska

Anna Kwiatkowska

Affiliations

Soon will be listed here.

Abstract

Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in patients with schizophrenia and healthy subjects. The level of superoxide anions generated in platelets after thrombin and platelet-activating factor stimulation and activity of GPx in patients with schizophrenia and healthy volunteers was estimated. The results obtained from the study indicate that the generation of superoxide anions in platelets as a response of platelets in patients with schizophrenia to such activating factors as thrombin or platelet-activating factor is higher than in the response of platelets of healthy subjects. In platelets from schizophrenic patients, suppressed GPx activity of about 67% was observed.

Citing Articles

Bioinformatics-based identification of CTSS, DOK2, and ENTPD1 as potential blood biomarkers of schizophrenia.

Zhang L, Zhang J, Wang N, Liu C, Wang S, Dong X BMC Psychiatry. 2025; 25(1):157.

PMID: 39972407 PMC: 11841330. DOI: 10.1186/s12888-025-06512-0.

Relevance of diet in schizophrenia: a review focusing on prenatal nutritional deficiency, obesity, oxidative stress and inflammation.

Rarinca V, Vasile A, Visternicu M, Burlui V, Halitchi G, Ciobica A Front Nutr. 2024; 11:1497569.

PMID: 39734678 PMC: 11673491. DOI: 10.3389/fnut.2024.1497569.

Superoxide dismutase and neurological disorders.

Chidambaram S, Anand N, Varma S, Ramamurthy S, Vichitra C, Sharma A IBRO Neurosci Rep. 2024; 16:373-394.

PMID: 39007083 PMC: 11240301. DOI: 10.1016/j.ibneur.2023.11.007.

Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review.

Birdi A, Tomo S, Yadav D, Sharma P, Nebhinani N, Mitra P Indian J Clin Biochem. 2023; 38(1):13-21.

PMID: 36684492 PMC: 9852376. DOI: 10.1007/s12291-022-01078-0.

The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.

Almulla A, Vasupanrajit A, Tunvirachaisakul C, Al-Hakeim H, Solmi M, Verkerk R Mol Psychiatry. 2022; 27(9):3679-3691.

PMID: 35422466 DOI: 10.1038/s41380-022-01552-4.

References

Yao J, Reddy R, McElhinny L, VAN KAMMEN D . Reduced status of plasma total antioxidant capacity in schizophrenia. Schizophr Res. 1998; 32(1):1-8. DOI: 10.1016/s0920-9964(98)00030-9. View

Plein H, Berk M . The platelet as a peripheral marker in psychiatric illness. Hum Psychopharmacol. 2002; 16(3):229-236. DOI: 10.1002/hup.251. View

Li H, Chen Q, Ma Y, Zhou J . Imbalanced free radicals and antioxidant defense systems in schizophrenia: a comparative study. J Zhejiang Univ Sci B. 2006; 7(12):981-6. PMC: 1661668. DOI: 10.1631/jzus.2006.B0981. View

Dietrich-Muszalska A, Olas B . Isoprostenes as indicators of oxidative stress in schizophrenia. World J Biol Psychiatry. 2009; 10(1):27-33. DOI: 10.1080/15622970701361263. View

Zhang M, Zhao Z, He L, Wan C . A meta-analysis of oxidative stress markers in schizophrenia. Sci China Life Sci. 2010; 53(1):112-124. DOI: 10.1007/s11427-010-0013-8. View

Lapetina E . The signal transduction induced by thrombin in human platelets. FEBS Lett. 1990; 268(2):400-4. DOI: 10.1016/0014-5793(90)81293-w. View

Nowak P, Olas B, Bald E, Glowacki R, Wachowicz B . Peroxynitrite-induced changes of thiol groups in human blood platelets. Platelets. 2003; 14(6):375-9. DOI: 10.1080/0953710032000141400. View

Ruschena D, Mullen P, Burgess P, Cordner S, Barry-Walsh J, Drummer O . Sudden death in psychiatric patients. Br J Psychiatry. 1998; 172:331-6. DOI: 10.1192/bjp.172.4.331. View

Fendri C, Mechri A, Khiari G, Othman A, Kerkeni A, Gaha L . [Oxidative stress involvement in schizophrenia pathophysiology: a review]. Encephale. 2006; 32(2 Pt 1):244-52. DOI: 10.1016/s0013-7006(06)76151-6. View

10.

Olas B, Nowak P, Kolodziejczyk J, Wachowicz B . The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thromb Res. 2004; 113(6):399-406. DOI: 10.1016/j.thromres.2004.04.002. View

11.

Dietrich-Muszalska A, Olas B . Modifications of blood platelet proteins of patients with schizophrenia. Platelets. 2009; 20(2):90-6. DOI: 10.1080/09537100802641499. View

12.

Dean O, Giorlando F, Berk M . N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2010; 36(2):78-86. PMC: 3044191. DOI: 10.1503/jpn.100057. View

13.

Allebeck P, Wistedt B . Mortality in schizophrenia. A ten-year follow-up based on the Stockholm County inpatient register. Arch Gen Psychiatry. 1986; 43(7):650-3. DOI: 10.1001/archpsyc.1986.01800070036005. View

14.

Do K, Trabesinger A, Lauer C, Dydak U, Hell D, Holsboer F . Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci. 2000; 12(10):3721-8. DOI: 10.1046/j.1460-9568.2000.00229.x. View

15.

Reddy R, Yao J . Free radical pathology in schizophrenia: a review. Prostaglandins Leukot Essent Fatty Acids. 1996; 55(1-2):33-43. DOI: 10.1016/s0952-3278(96)90143-x. View

16.

Sheehan D, Lecrubier Y, Sheehan K, Amorim P, Janavs J, Weiller E . The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1999; 59 Suppl 20:22-33;quiz 34-57. View

17.

Olas B, Wachowicz B . Role of reactive nitrogen species in blood platelet functions. Platelets. 2007; 18(8):555-65. DOI: 10.1080/09537100701504087. View

18.

Berry T . A selenium transport protein model of a sub-type of schizophrenia. Med Hypotheses. 1994; 43(6):409-14. DOI: 10.1016/0306-9877(94)90017-5. View

19.

Padurariu M, Ciobica A, Dobrin I, Stefanescu C . Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics. Neurosci Lett. 2010; 479(3):317-20. DOI: 10.1016/j.neulet.2010.05.088. View

20.

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View