Pancreatic Tumor Cell Secreted CCN1/Cyr61 Promotes Endothelial Cell Migration and Aberrant Neovascularization

Overview

Journal Sci Rep

Specialty Science

Date 2014 May 17

PMID 24833309

Citations 26

Authors

Gargi Maity

Smita Mehta

Inamul Haque

Kakali Dhar

Sandipto Sarkar

Sushanta K Banerjee

Snigdha Banerjee

Affiliations

Soon will be listed here.

Abstract

The complex signaling networks between cancer cells and adjacent endothelial cells make it challenging to unravel how cancer cells send extracellular messages to promote aberrant vascularization or tumor angiogenesis. Here, in vitro and in vivo models show that pancreatic cancer cell generated unique microenvironments can underlie endothelial cell migration and tumor angiogenesis. Mechanistically, we find that pancreatic cancer cell secreted CCN1/Cyr61 matricellular protein rewires the microenvironment to promote endothelial cell migration and tumor angiogenesis. This event can be overcome by Sonic Hedgehog (SHh) antibody treatment. Collectively, these studies identify a novel CCN1 signaling program in pancreatic cancer cells which activates SHh through autocrine-paracrine circuits to promote endothelial cell migration and tumor angiogenesis and suggests that CCN1 signaling of pancreatic cancer cells is vital for the regulation of tumor angiogenesis. Thus CCN1 signaling could be an ideal target for tumor vascular disruption in pancreatic cancer.

Citing Articles

The Crosstalk Analysis between mPSCs and Panc1 Cells Identifies CCN1 as a Positive Regulator of Gemcitabine Sensitivity in Pancreatic Cancer Cells.

Gundel B, Liu X, Pfutzenreuter A, Engelsberger V, Weiskirchen R, Lohr J Int J Mol Sci. 2024; 25(17).

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Multi-omics Analysis Revealed that the CCN Family Regulates Cell Crosstalk, Extracellular Matrix, and Immune Escape, Leading to a Poor Prognosis of Glioma.

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The role of CCNs in controlling cellular communication in the tumor microenvironment.

Birkeness L, Banerjee S, Quadir M, Banerjee S J Cell Commun Signal. 2022; 17(1):35-45.

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Zhang C, Zou Y, Zhu Y, Liu Y, Feng H, Niu F Front Med (Lausanne). 2021; 8:649326.

PMID: 33869254 PMC: 8047149. DOI: 10.3389/fmed.2021.649326.

CCN Family Proteins in Cancer: Insight Into Their Structures and Coordination Role in Tumor Microenvironment.

Jia Q, Xu B, Zhang Y, Ali A, Liao X Front Genet. 2021; 12:649387.

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