Expression and Function of Kisspeptin During Mouse Decidualization

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 May 17

PMID 24830702

Citations 18

Authors

Peng Zhang

Min Tang

Ting Zhong

Yan Lin

Teng Zong

Chengxue Zhong

Baoping Zhang

Min Ren

Haibin Kuang

Affiliations

Soon will be listed here.

Abstract

Background: Plasma kisspeptin levels dramatically increased during the first trimester of human pregnancy, which is similar to pregnancy specific glycoprotein-human chorionic gonadotropin. However, its particular role in the implantation and decidualization has not been fully unraveled. Here, the study was conducted to investigate the expression and function of kisspeptin in mouse uterus during early pregnancy and decidualization.

Methodology/principal Findings: Quantitative PCR results demonstrated that Kiss1 and GPR54 mRNA levels showed dynamic increase in the mouse uterus during early pregnancy and artificially induced decidualization in vivo. KISS-1 and GPR54 proteins were spatiotemporally expressed in decidualizing stromal cells in intact pregnant females, as well as in pseudopregnant mice undergoing artificially induced decidualization. In the ovariectomized mouse uterus, the expression of Kiss1 mRNA was upregulated after progesterone or/and estradiol treatment. Moreover, in a stromal cell culture model, the expression of Kiss1 and GPR54 mRNA gradually rise with the progression of stromal cell decidualization, whereas the attenuated expression of Kiss1 using small interfering RNA approaches significantly blocked the progression of stromal cell decidualization.

Conclusion: our results demonstrated that Kiss1/GPR54 system was involved in promoting uterine decidualization during early pregnancy in mice.

Citing Articles

Hypothyroidism Alters Uterine Kisspeptin System and Activity Modulators in Cyclic Rats.

da Silva T, Barbosa E, Santos L, Oliveira L, Cunha M, de Macedo I Int J Mol Sci. 2025; 26(2).

PMID: 39859259 PMC: 11765193. DOI: 10.3390/ijms26020543.

[Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in Endometrial Decidualization in Patients With Recurrent Spontaneous Abortion].

Yang Y, Zhang J, Li D, Liu C, Guo R, Xiao Y Sichuan Da Xue Xue Bao Yi Xue Ban. 2024; 55(3):542-551.

PMID: 38948287 PMC: 11211770. DOI: 10.12182/20240560206.

Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones.

Gomes V, Woods A, Crissman K, Landry C, Beckers K, Gilbert B Reprod Med (Basel). 2023; 3(4):263-279.

PMID: 37538930 PMC: 10399610. DOI: 10.3390/reprodmed3040021.

Immunohistochemistry of Leukemia Inhibitory Factor and Integrin αVβ3 in Mouse Endometrium Following Kisspeptin-54 Ovulation Trigger.

Abdelkareem A, Iews M, Ait-Allah A, Rasheed S, Helmy Y, Habte R Reprod Sci. 2023; 30(10):3084-3091.

PMID: 37126206 DOI: 10.1007/s43032-023-01243-7.

Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model.

Santos B, Dos Anjos Cordeiro J, Santos L, Barbosa E, Mendonca L, Santos E Front Endocrinol (Lausanne). 2022; 13:908240.

PMID: 35966095 PMC: 9365946. DOI: 10.3389/fendo.2022.908240.

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