Gabapentin in Acute Postoperative Pain Management

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 May 16

PMID 24829909

Citations 34

Authors

Connie Y Chang

Chaitanya K Challa

Janki Shah

Jean Daniel Eloy

Affiliations

Soon will be listed here.

Abstract

Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. Overall, gabapentin has been reported to be a safe and efficacious drug for the treatment of postoperative pain.

Citing Articles

Comparison of the Efficacy of Pregabalin and Gabapentin for Preemptive Analgesia in Laparoscopic Cholecystectomy Patients: A Randomised Double-Blind Study.

Kaur S, Turka S, Kaur Bindra T, Tuteja R, Kumar M, Bajwa S Cureus. 2023; 15(10):e46719.

PMID: 38021908 PMC: 10630708. DOI: 10.7759/cureus.46719.

Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial.

Hassanzadeh S, Bagheri S, Ahmadi S, Ahmadi S, Moradishibany I, Dolatkhah H BMC Endocr Disord. 2023; 23(1):224.

PMID: 37845651 PMC: 10577942. DOI: 10.1186/s12902-023-01486-0.

A retrospective analysis of pain and opioid usage in head and neck free flap reconstruction.

Towfighi P, Hill A, Crossley J, Walsh A, Leonard J, Giurintano J World J Otorhinolaryngol Head Neck Surg. 2023; 9(2):153-159.

PMID: 37383327 PMC: 10296052. DOI: 10.1002/wjo2.87.

Gabapentin for chronic refractory cough: A system review and meta-analysis.

Xie S, Xie M, Shen Y, Cheng D Heliyon. 2023; 9(5):e15579.

PMID: 37131438 PMC: 10149207. DOI: 10.1016/j.heliyon.2023.e15579.

Personalised 3D-Printed Mucoadhesive Gastroretentive Hydrophilic Matrices for Managing Overactive Bladder (OAB).

Khizer Z, Akram M, Tahir M, Liu W, Lou S, Conway B Pharmaceuticals (Basel). 2023; 16(3).

PMID: 36986471 PMC: 10056888. DOI: 10.3390/ph16030372.

References

Turan A, Karamanlioglu B, Memis D, Hamamcioglu M, Tukenmez B, Pamukcu Z . Analgesic effects of gabapentin after spinal surgery. Anesthesiology. 2004; 100(4):935-8. DOI: 10.1097/00000542-200404000-00025. View

Goa K, Sorkin E . Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993; 46(3):409-427. DOI: 10.2165/00003495-199346030-00007. View

WONG M, Eldon M, Keane W, Turck D, Bockbrader H, Underwood B . Disposition of gabapentin in anuric subjects on hemodialysis. J Clin Pharmacol. 1995; 35(6):622-6. DOI: 10.1002/j.1552-4604.1995.tb05020.x. View

Ho K, Gan T, Habib A . Gabapentin and postoperative pain--a systematic review of randomized controlled trials. Pain. 2006; 126(1-3):91-101. DOI: 10.1016/j.pain.2006.06.018. View

Sagirli O, Cetin S, Onal A . Determination of gabapentin in human plasma and urine by high-performance liquid chromatography with UV-vis detection. J Pharm Biomed Anal. 2006; 42(5):618-24. DOI: 10.1016/j.jpba.2006.05.012. View

Sihoe A, Lee T, Wan I, Thung K, Yim A . The use of gabapentin for post-operative and post-traumatic pain in thoracic surgery patients. Eur J Cardiothorac Surg. 2006; 29(5):795-9. DOI: 10.1016/j.ejcts.2006.02.020. View

Dahl J, Mathiesen O, Moiniche S . 'Protective premedication': an option with gabapentin and related drugs? A review of gabapentin and pregabalin in in the treatment of post-operative pain. Acta Anaesthesiol Scand. 2004; 48(9):1130-6. DOI: 10.1111/j.1399-6576.2004.00484.x. View

Hooper W, Kavanagh M, Dickinson R . Determination of gabapentin in plasma and urine by capillary column gas chromatography. J Chromatogr. 1990; 529(1):167-74. DOI: 10.1016/s0378-4347(00)83818-9. View

Ben-Menachem E, Persson L, Hedner T . Selected CSF biochemistry and gabapentin concentrations in the CSF and plasma in patients with partial seizures after a single oral dose of gabapentin. Epilepsy Res. 1992; 11(1):45-9. DOI: 10.1016/0920-1211(92)90020-t. View

10.

Zapp J . Postpoliomyelitis pain treated with gabapentin. Am Fam Physician. 1996; 53(8):2442, 2445. View

11.

HENGY H, Kolle E . Determination of gabapentin in plasma and urine by high-performance liquid chromatography and pre-column labelling for ultraviolet detection. J Chromatogr. 1985; 341(2):473-8. DOI: 10.1016/s0378-4347(00)84064-5. View

12.

Solak O, Metin M, Esme H, Solak O, Yaman M, Pekcolaklar A . Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur J Cardiothorac Surg. 2007; 32(1):9-12. DOI: 10.1016/j.ejcts.2007.03.022. View

13.

Rose M, Kam P . Gabapentin: pharmacology and its use in pain management. Anaesthesia. 2002; 57(5):451-62. DOI: 10.1046/j.0003-2409.2001.02399.x. View

14.

Huot M, Chouinard P, Girard F, Ruel M, Lafontaine E, Ferraro P . Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study. Can J Anaesth. 2008; 55(6):337-43. DOI: 10.1007/BF03021488. View

15.

Beal B, Moeller-Bertram T, Schilling J, Wallace M . Gabapentin for once-daily treatment of post-herpetic neuralgia: a review. Clin Interv Aging. 2012; 7:249-55. PMC: 3410680. DOI: 10.2147/CIA.S23783. View

16.

Zakkar M, Frazer S, Hunt I . Is there a role for gabapentin in preventing or treating pain following thoracic surgery?. Interact Cardiovasc Thorac Surg. 2013; 17(4):716-9. PMC: 3781811. DOI: 10.1093/icvts/ivt301. View

17.

Schlicker E, Reimann W, Gothert M . Gabapentin decreases monoamine release without affecting acetylcholine release in the brain. Arzneimittelforschung. 1985; 35(9):1347-9. View

18.

Hill D, Woodruff G . Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies. Eur J Pharmacol. 1993; 244(3):303-9. DOI: 10.1016/0922-4106(93)90156-4. View

19.

Kinney M, Mantilla C, Carns P, Passe M, Brown M, Hooten W . Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study. Pain Pract. 2011; 12(3):175-83. PMC: 3200555. DOI: 10.1111/j.1533-2500.2011.00480.x. View

20.

Rosner H, Rubin L, Kestenbaum A . Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain. 1996; 12(1):56-8. DOI: 10.1097/00002508-199603000-00010. View