MicroRNA-26a-5p and MicroRNA-23b-3p Up-regulate Peroxiredoxin III in Acute Myeloid Leukemia

Overview

Journal Leuk Lymphoma

Specialties Hematology
Oncology

Date 2014 May 16

PMID 24828865

Citations 18

Authors

Wenjie Jiang

Jie Min

Xiaohui Sui

Yanyan Qian

Ying Liu

Zhaojian Liu

Haibin Zhou

Xi Li

Yaoqin Gong

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small RNAs that regulate target gene expression. Using microarray-based miRNA expression profiling, we compared the miRNA expression in granulocytes from four patients with acute myeloid leukemia and four healthy controls. Thirty-four miRNAs were found to be differentially expressed, including 20 miRNAs that were up-regulated and 14 miRNAs that were down-regulated. The expression of selected miRNAs (miR-26a-5p and miR-23b-3p) was independently validated in 20 patients and 12 healthy controls. Notably, we demonstrated that peroxiredoxin III (PrxIII) is a common direct target of both miR-26a-5p and miR-23b-3p. Furthermore, these results indicate that the two decreased miRNAs could scavenge cellular reactive oxygen species (ROS) by targeting the PrxIII gene. These findings are discussed with regard to the known function of PrxIII as a ROS scavenger and the high endogenous ROS levels required for hematopoietic stem cell differentiation. These findings may potentially offer insights into the pathological relationships between miR-26a-5p, miR-23b-3p and leukemogenesis.

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References

Krek A, Grun D, Poy M, Wolf R, Rosenberg L, Epstein E . Combinatorial microRNA target predictions. Nat Genet. 2005; 37(5):495-500. DOI: 10.1038/ng1536. View

Erdogan B, Bosompem A, Peng D, Han L, Smith E, Kennedy M . Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. Leuk Lymphoma. 2013; 54(12):2720-7. PMC: 4120331. DOI: 10.3109/10428194.2013.790542. View

Callens C, Coulon S, Naudin J, Radford-Weiss I, Boissel N, Raffoux E . Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010; 207(4):731-50. PMC: 2856037. DOI: 10.1084/jem.20091488. View

Agrawal-Singh S, Isken F, Agelopoulos K, Klein H, Thoennissen N, Koehler G . Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. Blood. 2011; 119(10):2346-57. DOI: 10.1182/blood-2011-06-358705. View

Li Z, Lu J, Sun M, Mi S, Zhang H, Luo R . Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A. 2008; 105(40):15535-40. PMC: 2563085. DOI: 10.1073/pnas.0808266105. View

Monteiro G, Horta B, Pimenta D, Augusto O, Netto L . Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proc Natl Acad Sci U S A. 2007; 104(12):4886-91. PMC: 1829234. DOI: 10.1073/pnas.0700481104. View

Sutherland J, Turner A, Mannoni P, McGann L, Turc J . Differentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages. J Biol Response Mod. 1986; 5(3):250-62. View

Liu S, Wu L, Pang J, Santhanam R, Schwind S, Wu Y . Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell. 2010; 17(4):333-47. PMC: 2917066. DOI: 10.1016/j.ccr.2010.03.008. View

Choi J, Kim T, Kim S, Baek S, Kim J, Lee S . Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. Anticancer Res. 2003; 22(6A):3331-5. View

10.

Kang S, Rhee S, Chang T, Jeong W, Choi M . 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends Mol Med. 2005; 11(12):571-8. PMC: 7185838. DOI: 10.1016/j.molmed.2005.10.006. View

11.

Zaman M, Thamminana S, Shahryari V, Chiyomaru T, Deng G, Saini S . Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer. PLoS One. 2012; 7(11):e50203. PMC: 3506541. DOI: 10.1371/journal.pone.0050203. View

12.

Wang G, Zhang H, He H, Tong W, Wang B, Liao G . Up-regulation of microRNA in bladder tumor tissue is not common. Int Urol Nephrol. 2009; 42(1):95-102. DOI: 10.1007/s11255-009-9584-3. View

13.

Garzon R, Croce C . MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol. 2008; 15(4):352-8. DOI: 10.1097/MOH.0b013e328303e15d. View

14.

Wu L, Belasco J . Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs. Mol Cell. 2008; 29(1):1-7. DOI: 10.1016/j.molcel.2007.12.010. View

15.

Muller F, Lustgarten M, Jang Y, Richardson A, Van Remmen H . Trends in oxidative aging theories. Free Radic Biol Med. 2007; 43(4):477-503. DOI: 10.1016/j.freeradbiomed.2007.03.034. View

16.

Lowenberg B, Downing J, Burnett A . Acute myeloid leukemia. N Engl J Med. 1999; 341(14):1051-62. DOI: 10.1056/NEJM199909303411407. View

17.

Marcucci G, Mrozek K, Radmacher M, Garzon R, Bloomfield C . The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood. 2010; 117(4):1121-9. PMC: 3056468. DOI: 10.1182/blood-2010-09-191312. View

18.

Rhee S, Chae H, Kim K . Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med. 2005; 38(12):1543-52. DOI: 10.1016/j.freeradbiomed.2005.02.026. View

19.

Salvatori B, Iosue I, Mangiavacchi A, Loddo G, Padula F, Chiaretti S . The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells. Cell Death Dis. 2012; 3:e413. PMC: 3481138. DOI: 10.1038/cddis.2012.151. View

20.

Garzon R, Volinia S, Liu C, Fernandez-Cymering C, Palumbo T, Pichiorri F . MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood. 2008; 111(6):3183-9. PMC: 2265455. DOI: 10.1182/blood-2007-07-098749. View