Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2014 May 15

PMID 24824685

Citations 9

Authors

T E Kononova

O I Urazova

V V Novitskii

E G Churina

Yu V Kolobovnikova

M V Ignatov

P A Zakharova

O V Pechenova

Affiliations

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Abstract

Increased content of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.

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