Evaluating the Sensitivity of Hybridization-based Epigenotyping Using a Methyl Binding Domain Protein

Overview

Journal Analyst

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 May 15

PMID 24824477

Citations 7

Authors

Brandon W Heimer

Tatyana A Shatova

Jungkyu K Lee

Kaja Kaastrup

Hadley D Sikes

Affiliations

Soon will be listed here.

Abstract

Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.

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