Temporal Dysfunction in Traumatic Brain Injury Patients: Primary or Secondary Impairment?

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2014 May 13

PMID 24817847

Citations 19

Authors

Giovanna Mioni

Simon Grondin

Franca Stablum

Affiliations

Soon will be listed here.

Abstract

Adequate temporal abilities are required for most daily activities. Traumatic brain injury (TBI) patients often present with cognitive dysfunctions, but few studies have investigated temporal impairments associated with TBI. The aim of the present work is to review the existing literature on temporal abilities in TBI patients. Particular attention is given to the involvement of higher cognitive processes in temporal processing in order to determine if any temporal dysfunction observed in TBI patients is due to the disruption of an internal clock or to the dysfunction of general cognitive processes. The results showed that temporal dysfunctions in TBI patients are related to the deficits in cognitive functions involved in temporal processing rather than to a specific impairment of the internal clock. In fact, temporal dysfunctions are observed when the length of temporal intervals exceeds the working memory span or when the temporal tasks require high cognitive functions to be performed. The consistent higher temporal variability observed in TBI patients is a sign of impaired frontally mediated cognitive functions involved in time perception.

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References

Grondin S . Timing and time perception: a review of recent behavioral and neuroscience findings and theoretical directions. Atten Percept Psychophys. 2010; 72(3):561-82. DOI: 10.3758/APP.72.3.561. View

Zakay D, Block R . Prospective and retrospective duration judgments: an executive-control perspective. Acta Neurobiol Exp (Wars). 2004; 64(3):319-28. DOI: 10.55782/ane-2004-1516. View

Grondin S . Overloading temporal memory. J Exp Psychol Hum Percept Perform. 2005; 31(5):869-879. DOI: 10.1037/0096-1523.31.5.869. View

Mioni G, Stablum F, McClintock S, Cantagallo A . Time-based prospective memory in severe traumatic brain injury patients: the involvement of executive functions and time perception. J Int Neuropsychol Soc. 2012; 18(4):697-705. DOI: 10.1017/S1355617712000306. View

Grondin S, Ouellet B, Roussel M . Benefits and limits of explicit counting for discriminating temporal intervals. Can J Exp Psychol. 2004; 58(1):1-12. DOI: 10.1037/h0087436. View

Rubia K, Taylor A, Taylor E, Sergeant J . Synchronization, anticipation, and consistency in motor timing of children with dimensionally defined attention deficit hyperactivity behaviour. Percept Mot Skills. 2000; 89(3 Pt 2):1237-58. DOI: 10.2466/pms.1999.89.3f.1237. View

Brouwer W, Ponds R, van Wolffelaar P, van Zomeren A . Divided attention 5 to 10 years after severe closed head injury. Cortex. 1989; 25(2):219-30. DOI: 10.1016/s0010-9452(89)80038-3. View

Tobin S, Bisson N, Grondin S . An ecological approach to prospective and retrospective timing of long durations: a study involving gamers. PLoS One. 2010; 5(2):e9271. PMC: 2822850. DOI: 10.1371/journal.pone.0009271. View

Stanford M, BARRATT E . Verbal skills, finger tapping, and cognitive tempo define a second-order factor of temporal information processing. Brain Cogn. 1996; 31(1):35-45. DOI: 10.1006/brcg.1996.0023. View

10.

Hemmes N, Brown B, Kladopoulos C . Time perception with and without a concurrent nontemporal task. Percept Psychophys. 2004; 66(2):328-41. DOI: 10.3758/bf03194882. View

11.

Kagerer F, Wittmann M, Szelag E, V Steinbuchel N . Cortical involvement in temporal reproduction: evidence for differential roles of the hemispheres. Neuropsychologia. 2001; 40(3):357-66. DOI: 10.1016/s0028-3932(01)00111-7. View

12.

Jones L, Wearden J . Double standards: memory loading in temporal reference memory. Q J Exp Psychol B. 2003; 57(1):55-77. DOI: 10.1080/02724990344000088. View

13.

Rubia K, Schuri U, von Cramon D, Poeppel E . Time estimation as a neuronal network property: a lesion study. Neuroreport. 1997; 8(5):1273-6. DOI: 10.1097/00001756-199703240-00043. View

14.

Zakay D . Time estimation methods--do they influence prospective duration estimates?. Perception. 1993; 22(1):91-101. DOI: 10.1068/p220091. View

15.

Casini L, Ivry R . Effects of divided attention on temporal processing in patients with lesions of the cerebellum or frontal lobe. Neuropsychology. 1999; 13(1):10-21. DOI: 10.1037//0894-4105.13.1.10. View

16.

Levin H, ODonnell V, Grossman R . The Galveston Orientation and Amnesia Test. A practical scale to assess cognition after head injury. J Nerv Ment Dis. 1979; 167(11):675-84. DOI: 10.1097/00005053-197911000-00004. View

17.

Grondin S . From physical time to the first and second moments of psychological time. Psychol Bull. 2001; 127(1):22-44. DOI: 10.1037/0033-2909.127.1.22. View

18.

Rao S, Mayer A, Harrington D . The evolution of brain activation during temporal processing. Nat Neurosci. 2001; 4(3):317-23. DOI: 10.1038/85191. View

19.

Gibbon J, Church R, Meck W . Scalar timing in memory. Ann N Y Acad Sci. 1984; 423:52-77. DOI: 10.1111/j.1749-6632.1984.tb23417.x. View

20.

Brown S . Time perception and attention: the effects of prospective versus retrospective paradigms and task demands on perceived duration. Percept Psychophys. 1985; 38(2):115-24. DOI: 10.3758/bf03198848. View