ECT: Its Brain Enabling Effects: a Review of Electroconvulsive Therapy-induced Structural Brain Plasticity

Overview

Journal J ECT

Date 2014 May 10

PMID 24810772

Citations 59

Authors

Filip Bouckaert

Pascal Sienaert

Jasmien Obbels

Annemieke Dols

Mathieu Vandenbulcke

Max Stek

Tom Bolwig

Affiliations

Soon will be listed here.

Abstract

Background: Since the past 2 decades, new evidence for brain plasticity has caused a shift in both preclinical and clinical ECT research from falsifying the "brain damage hypothesis" toward exploring ECT's enabling brain (neuro)plasticity effects.

Methods: By reviewing the available animal and human literature, we examined the theory that seizure-induced structural changes are crucial for the therapeutic efficacy of ECT.

Results: Both animal and human studies suggest electroconvulsive stimulation/electroconvulsive therapy (ECT)-related neuroplasticity (neurogenesis, synaptogenesis, angiogenesis, or gliogenesis).

Conclusion: It remains unclear whether structural changes might explain the therapeutic efficacy and/or be related to the (transient) learning and memory impairment after ECT. Methods to assess in vivo brain plasticity of patients treated with ECT will be of particular importance for future longitudinal studies to give support to the currently available correlational data.

Citing Articles

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Evaluating Anesthesia Practices, Patient Characteristics, and Outcomes in Electroconvulsive Therapy: A Two-Year Retrospective Study.

Vintila B, Anghel C, Sava M, Bereanu A, Codru I, Stoica R J Clin Med. 2024; 13(20).

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Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT).

Cojocaru A, Vasile A, Trifu S Rom J Morphol Embryol. 2024; 65(1):13-17.

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Neurogenesis-independent mechanisms of MRI-detectable hippocampal volume increase following electroconvulsive stimulation.

Abe Y, Yokoyama K, Kato T, Yagishita S, Tanaka K, Takamiya A Neuropsychopharmacology. 2024; 49(8):1236-1245.

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Shenoy S, Ibrahim S Behav Sci (Basel). 2023; 13(11).

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