Does the Microbiome Play a Causal Role in Spondyloarthritis?

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2014 May 10

PMID 24810703

Citations 10

Authors

James T Rosenbaum

Phoebe Lin

Mark Asquith

Mary-Ellen Costello

Tony J Kenna

Matthew A Brown

Affiliations

Soon will be listed here.

Abstract

The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.

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