Cancer Risks in Aluminum Reduction Plant Workers: a Review

Overview

Journal J Occup Environ Med

Specialty Environmental Health

Date 2014 May 9

PMID 24806725

Citations 9

Authors

Graham W Gibbs

France Labreche

Affiliations

Soon will be listed here.

Abstract

Objective And Methods: This review examines epidemiological evidence relating to cancers in the primary aluminum industry where most of what is known relates to Söderberg operations or to mixed Söderberg/prebake operations.

Results And Conclusions: Increased lung and bladder cancer risks have been reported in Söderberg workers from several countries, but not in all. After adjustment for smoking, these cancer risks still increase with cumulative exposure to benzo(a)pyrene, used as an index of coal tar pitch volatiles exposure. Limited evidence has been gathered in several cohorts for an increased risk of tumors at other sites, including stomach, pancreas, rectum/rectosigmoid junction, larynx, buccal cavity/pharynx, kidney, brain/nervous system, prostate, and lymphatic/hematopoietic tissues (in particular non-Hodgkin lymphoma, Hodgkin disease, and leukemia). Nevertheless, for most of these tumor sites, the relationship with specific exposures has not been demonstrated clearly and further follow-up of workers is warranted.

Citing Articles

LncRNA-ENST00000556926 regulates the proliferation, apoptosis and mRNA transcriptome of malignant-transformed BEAS-2B cells induced by coal tar pitch.

Zhu Y, Li Z, Wang W, Jing L, Yu Q, Li Z Toxicol Res (Camb). 2021; 10(6):1144-1152.

PMID: 34956617 PMC: 8692750. DOI: 10.1093/toxres/tfab097.

Occupational Risk Factors for Prostate Cancer: A Meta-analysis.

Krstev S, Knutsson A J Cancer Prev. 2019; 24(2):91-111.

PMID: 31360689 PMC: 6619854. DOI: 10.15430/JCP.2019.24.2.91.

Yu S, Yan Z, Feng F, Ni J, Wang W, Nabie K Oncol Lett. 2018; 15(4):5143-5148.

PMID: 29552149 PMC: 5840710. DOI: 10.3892/ol.2018.7924.

Coal tar pitch extract could induce chromosomal instability of human bronchial epithelial cells mediated by spindle checkpoint-related proteins.

Zhang P, Li Z, Wang N, Duan G, Wang W, Feng Y Oncotarget. 2017; 8(34):56506-56517.

PMID: 28915607 PMC: 5593578. DOI: 10.18632/oncotarget.17025.

Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers.

Shrestha D, Liu S, Hammond S, LaValley M, Weiner D, Eisen E Occup Environ Med. 2016; 73(10):656-62.

PMID: 27484955 PMC: 5045439. DOI: 10.1136/oemed-2016-103769.

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