How Free Retinol Behaves Differently from Rbp-bound Retinol in RBP Receptor-mediated Vitamin A Uptake

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2014 May 8

PMID 24803602

Citations 8

Authors

Ming Zhong

Riki Kawaguchi

Miki Kassai

Hui Sun

Affiliations

Soon will be listed here.

Citing Articles

An in vitro model for vitamin A transport across the human blood-brain barrier.

Est C, Murphy R Elife. 2023; 12.

PMID: 37934575 PMC: 10629827. DOI: 10.7554/eLife.87863.

Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease.

Steinhoff J, Lass A, Schupp M Nutrients. 2022; 14(6).

PMID: 35334893 PMC: 8951293. DOI: 10.3390/nu14061236.

The role of retinoic acid in the commitment to meiosis.

Gewiss R, Schleif M, Griswold M Asian J Androl. 2021; 23(6):549-554.

PMID: 34472453 PMC: 8577254. DOI: 10.4103/aja202156.

Biological Functions of RBP4 and Its Relevance for Human Diseases.

Steinhoff J, Lass A, Schupp M Front Physiol. 2021; 12:659977.

PMID: 33790810 PMC: 8006376. DOI: 10.3389/fphys.2021.659977.

Spermatogenesis: The Commitment to Meiosis.

Griswold M Physiol Rev. 2015; 96(1):1-17.

PMID: 26537427 PMC: 4698398. DOI: 10.1152/physrev.00013.2015.

References

Kawaguchi R, Zhong M, Kassai M, Ter-Stepanian M, Sun H . STRA6-catalyzed vitamin A influx, efflux, and exchange. J Membr Biol. 2012; 245(11):731-45. PMC: 3770467. DOI: 10.1007/s00232-012-9463-1. View

Berry D, Croniger C, Ghyselinck N, Noy N . Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6. Mol Cell Biol. 2012; 32(19):3851-9. PMC: 3457529. DOI: 10.1128/MCB.00775-12. View

Erikstrup C, Mortensen O, Nielsen A, Fischer C, Plomgaard P, Petersen A . RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes. Diabetes Obes Metab. 2009; 11(3):204-12. DOI: 10.1111/j.1463-1326.2008.00901.x. View

Zhong M, Kawaguchi R, Kassai M, Sun H . Retina, retinol, retinal and the natural history of vitamin A as a light sensor. Nutrients. 2013; 4(12):2069-96. PMC: 3546623. DOI: 10.3390/nu4122069. View

Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P . A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007; 315(5813):820-5. DOI: 10.1126/science.1136244. View

Norseen J, Hosooka T, Hammarstedt A, Yore M, Kant S, Aryal P . Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012; 32(10):2010-9. PMC: 3347417. DOI: 10.1128/MCB.06193-11. View

Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M . Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012; 53(6):3027-39. PMC: 3378086. DOI: 10.1167/iovs.11-8476. View

Kawaguchi R, Yu J, Wiita P, Ter-Stepanian M, Sun H . Mapping the membrane topology and extracellular ligand binding domains of the retinol binding protein receptor. Biochemistry. 2008; 47(19):5387-95. PMC: 3907178. DOI: 10.1021/bi8002082. View

Kawaguchi R, Yu J, Wiita P, Honda J, Sun H . An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism. J Biol Chem. 2008; 283(22):15160-8. PMC: 2397481. DOI: 10.1074/jbc.M801060200. View

10.

Quadro L, Hamberger L, Colantuoni V, Gottesman M, Blaner W . Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Mol Aspects Med. 2003; 24(6):421-30. DOI: 10.1016/s0098-2997(03)00038-4. View

11.

Mills J, Furr H, Tanumihardjo S . Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Exp Biol Med (Maywood). 2008; 233(10):1255-61. PMC: 2692548. DOI: 10.3181/0803-RM-94. View

12.

Quadro L, Blaner W, Salchow D, Vogel S, Piantedosi R, Gouras P . Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999; 18(17):4633-44. PMC: 1171537. DOI: 10.1093/emboj/18.17.4633. View

13.

Seeliger M, Biesalski H, Wissinger B, Gollnick H, Gielen S, Frank J . Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999; 40(1):3-11. View

14.

Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y . RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab. 2008; 7(3):258-68. PMC: 2561276. DOI: 10.1016/j.cmet.2008.01.009. View

15.

Folli C, Viglione S, Busconi M, Berni R . Biochemical basis for retinol deficiency induced by the I41N and G75D mutations in human plasma retinol-binding protein. Biochem Biophys Res Commun. 2005; 336(4):1017-22. DOI: 10.1016/j.bbrc.2005.08.227. View

16.

Kawaguchi R, Yu J, Ter-Stepanian M, Zhong M, Cheng G, Yuan Q . Receptor-mediated cellular uptake mechanism that couples to intracellular storage. ACS Chem Biol. 2011; 6(10):1041-51. PMC: 3199320. DOI: 10.1021/cb200178w. View

17.

Quadro L, Hamberger L, Gottesman M, Colantuoni V, Ramakrishnan R, Blaner W . Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester. Am J Physiol Endocrinol Metab. 2004; 286(5):E844-51. DOI: 10.1152/ajpendo.00556.2003. View

18.

Quadro L, Hamberger L, Gottesman M, Wang F, Colantuoni V, Blaner W . Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Endocrinology. 2005; 146(10):4479-90. DOI: 10.1210/en.2005-0158. View

19.

Nau H . Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid. J Am Acad Dermatol. 2001; 45(5):S183-7. DOI: 10.1067/mjd.2001.113720. View

20.

Farjo K, Farjo R, Halsey S, Moiseyev G, Ma J . Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012; 32(24):5103-15. PMC: 3510526. DOI: 10.1128/MCB.00820-12. View