Human Pluripotent Stem Cell-derived Cardiomyocytes As Research and Therapeutic Tools

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 May 7

PMID 24800237

Citations 23

Authors

Ivana Acimovic

Aleksandra Vilotic

Martin Pesl

Alain Lacampagne

Petr Dvorak

Vladimir Rotrekl

Albano C Meli

Affiliations

Soon will be listed here.

Abstract

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).

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