Impaired Urine Dilution Capability in HIV Stable Patients

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2014 May 7

PMID 24800076

Citations 6

Authors

Waldo H Belloso

Mariana De Paz Sierra

Matilde Navarro

Marisa L Sanchez

Ariel G Perelsztein

Carlos G Musso

Affiliations

Soon will be listed here.

Abstract

Renal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle's loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney's ability to dilute urine. Objective. We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz' test). Material & Methods. Chaimowitz' test was performed on 20 HIV positive volunteers who had normal renal functional parameters. The control group included 10 healthy volunteers. Results. After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group. Free water clearance was lower and urine osmolarity was higher in both HIV+ groups. Proximal tubular function was normal in both studied groups. Conclusion. The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir.

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References

Hall A, Edwards S, Lapsley M, Connolly J, Chetty K, OFarrell S . Subclinical tubular injury in HIV-infected individuals on antiretroviral therapy: a cross-sectional analysis. Am J Kidney Dis. 2009; 54(6):1034-42. DOI: 10.1053/j.ajkd.2009.07.012. View

Vashistha H, Husain M, Kumar D, Singhal P . Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis. Ren Fail. 2009; 31(4):303-12. DOI: 10.1080/08860220902780101. View

Choi A, Scherzer R, Bacchetti P, Tien P, Saag M, Gibert C . Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons. Am J Kidney Dis. 2010; 56(5):872-82. PMC: 3164880. DOI: 10.1053/j.ajkd.2010.05.019. View

Musso C, Macias-Nunez J . Dysfunction of the thick loop of Henle and senescence: from molecular biology to clinical geriatrics. Int Urol Nephrol. 2010; 43(1):249-52. DOI: 10.1007/s11255-010-9783-y. View

Estrella M, Fine D, Atta M . Recent developments in HIV-related kidney disease. HIV Ther. 2011; 4(5):589-603. PMC: 3038636. DOI: 10.2217/hiv.10.42. View

Choi A, Li Y, Deeks S, Grunfeld C, Volberding P, Shlipak M . Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons. Circulation. 2010; 121(5):651-8. PMC: 2829672. DOI: 10.1161/CIRCULATIONAHA.109.898585. View

Gardner L, Holmberg S, Williamson J, Szczech L, Carpenter C, Rompalo A . Development of proteinuria or elevated serum creatinine and mortality in HIV-infected women. J Acquir Immune Defic Syndr. 2003; 32(2):203-9. DOI: 10.1097/00126334-200302010-00013. View

Szczech L . Renal dysfunction and tenofovir toxicity in HIV-infected patients. Top HIV Med. 2008; 16(4):122-6. View

Kalayjian R . Kidney Disease in HIV-Infected Persons. Curr Infect Dis Rep. 2011; 14(1):83-90. DOI: 10.1007/s11908-011-0228-2. View

10.

Labarga P, Barreiro P, Martin-Carbonero L, Rodriguez-Novoa S, Solera C, Medrano J . Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS. 2009; 23(6):689-96. DOI: 10.1097/QAD.0b013e3283262a64. View

11.

Mathew G, Knaus S . Acquired Fanconi's syndrome associated with tenofovir therapy. J Gen Intern Med. 2006; 21(11):C3-5. PMC: 1831672. DOI: 10.1111/j.1525-1497.2006.00518.x. View

12.

Decaux G, Vandergheynst F, Bouko Y, Parma J, Vassart G, Vilain C . Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree. J Am Soc Nephrol. 2007; 18(2):606-12. DOI: 10.1681/ASN.2006090987. View

13.

Menon M, Garcha A, Khanna A . The management of hyponatremia in HIV disease. J Nephrol. 2012; 26(1):61-72. DOI: 10.5301/jn.5000168. View

14.

Cooper R, Wiebe N, Smith N, Keiser P, Naicker S, Tonelli M . Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients. Clin Infect Dis. 2010; 51(5):496-505. DOI: 10.1086/655681. View

15.

Rodriguez-Novoa S, Alvarez E, Labarga P, Soriano V . Renal toxicity associated with tenofovir use. Expert Opin Drug Saf. 2010; 9(4):545-59. DOI: 10.1517/14740331003627458. View

16.

Fernandez-Fernandez B, Montoya-Ferrer A, Sanz A, Sanchez-Nino M, Izquierdo M, Poveda J . Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat. 2011; 2011:354908. PMC: 3119412. DOI: 10.1155/2011/354908. View

17.

Gupta S, Eustace J, Winston J, Boydstun I, Ahuja T, Rodriguez R . Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2005; 40(11):1559-85. DOI: 10.1086/430257. View

18.

Macias Nunez J, Garcia Iglesias C, Bondia Roman A, Rodriguez Commes J, Corbacho Becerra L, Romo J . Renal handling of sodium in old people: a functional study. Age Ageing. 1978; 7(3):178-81. DOI: 10.1093/ageing/7.3.178. View

19.

Phair J, Palella F . Renal disease in HIV-infected individuals. Curr Opin HIV AIDS. 2011; 6(4):285-9. PMC: 3266688. DOI: 10.1097/COH.0b013e3283476bc3. View

20.

Wyatt C, Hoover D, Shi Q, Seaberg E, Wei C, Tien P . Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. J Acquir Immune Defic Syndr. 2010; 55(1):73-7. PMC: 2888617. DOI: 10.1097/QAI.0b013e3181cc1070. View