Drosophila Blood Cell Chemotaxis

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2014 May 7

PMID 24799191

Citations 17

Authors

Iwan Robert Evans

Will Wood

Affiliations

Soon will be listed here.

Abstract

Drosophila melanogaster contains a population of blood cells called hemocytes that represent the functional equivalent of vertebrate macrophages. These cells undergo directed migrations to disperse during development and reach sites of tissue damage or altered self. These chemotactic behaviors are controlled by the expression of PDGF/Vegf-related ligands in developing embryos and local production of hydrogen peroxide at wounds. Recent work reveals that many molecules important in vertebrate cell motility, including integrins, formins, Ena/VASP proteins and the SCAR/WAVE complex, have a conserved function in these innate immune cells. The use of this model organism has elucidated how damage signals are activated by calcium signaling during inflammation and that the steroid hormone ecdysone activates immune competence at key developmental stages.

Citing Articles

Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis.

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Hematopoietic plasticity mapped in and other insects.

Hultmark D, Ando I Elife. 2022; 11.

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Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury.

Ramond E, Dudzic J, Lemaitre B PLoS One. 2020; 15(6):e0235294.

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Chemotaxis Assay for Hemocytes and Application for the Development of an Oral Immunostimulant Against White Spot Syndrome Virus.

Imai T, Takahashi Y Front Cell Dev Biol. 2020; 8:46.

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