Rsf-1 Overexpression Serves As a Prognostic Marker in Human Hepatocellular Carcinoma

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2014 May 7

PMID 24798976

Citations 8

Authors

ChengYao Xie

Lin Fu

Lingling Xie

Nan Liu

Qingchang Li

Affiliations

Soon will be listed here.

Abstract

Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human hepatocellular carcinoma (HCC) have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human HCC tissues and found that Rsf-1 was overexpressed in 41.1 % of HCC specimens. There was a significant association between Rsf-1 overexpression and tumor stage (p = 0.0322), AFP (p = 0.0184), and tumor relapse (p = 0.0112). Furthermore, Rsf-1 overexpression correlated with poor overall survival in HCC patients (p < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival (p = 0.0079). Small interfering RNA (siRNA) knockdown in SK-Hep-1 cells with high endogenous Rsf-1 expression inhibited cell proliferation and colony formation, with downregulation of cyclin E protein. In conclusion, Rsf-1 is overexpressed in HCCs and serves as a novel tumor marker. Rsf-1 contributes to hepatocellular carcinoma cell growth through regulation of cell cycle proteins.

Citing Articles

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Rsf‑1 regulates malignant melanoma cell viability and chemoresistance via NF‑κB/Bcl‑2 signaling.

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Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks.

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Effects of RSF-1 on proliferation and apoptosis of breast cancer cells.

Liu Y, Gai J, Fu L, Zhang X, Wang E, Li Q Oncol Lett. 2018; 16(4):4279-4284.

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RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer.

Wang X, Sheu J, Lai M, Chang C, Sheng X, Wei L Biomedicine (Taipei). 2018; 8(1):4.

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