Identification of Specific Y Chromosomes Associated with Increased Prostate Cancer Risk

Overview

Journal Prostate

Date 2014 May 7

PMID 24796687

Citations 5

Authors

Lisa A Cannon-Albright

James M Farnham

Matthew Bailey

Frederick S Albright

Craig C Teerlink

Neeraj Agarwal

Robert A Stephenson

Alun Thomas

Affiliations

Soon will be listed here.

Abstract

Background: Evidence supports the possibility of a role of the Y chromosome in prostate cancer, but controversy exists.

Methods: A novel analysis of a computerized population-based resource linking genealogy and cancer data was used to test the hypothesis of a role of the Y chromosome in prostate cancer predisposition. Using a statewide cancer registry from 1966 linked to a computerized genealogy representing over 1.2 million descendants of the Utah pioneers, 1,000 independent sets of males, each set hypothesized to share the same Y chromosome as represented in genealogy data, were tested for a significant excess of prostate cancer.

Results: Multiple Y chromosomes representing thousands of potentially at-risk males were identified to have a significant excess risk for prostate cancer.

Conclusions: This powerful and efficient in silico test of an uncommon mode of inheritance has confirmed evidence for Y chromosome involvement in prostate cancer.

Citing Articles

A review of studies examining the association between genetic biomarkers (short tandem repeats and single-nucleotide polymorphisms) and risk of prostate cancer: the need for valid predictive biomarkers.

Albujja M, Vasudevan R, Alghamdi S, Pei C, Bin Mohd Ghani K, Ranneh Y Prostate Int. 2021; 8(4):135-145.

PMID: 33425790 PMC: 7767939. DOI: 10.1016/j.prnil.2019.11.003.

Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.

Godfrey A, Naqvi S, Chmatal L, Chick J, Mitchell R, Gygi S Genome Res. 2020; 30(6):860-873.

PMID: 32461223 PMC: 7370882. DOI: 10.1101/gr.261248.120.

Mosaic loss of human Y chromosome: what, how and why.

Guo X, Dai X, Zhou T, Wang H, Ni J, Xue J Hum Genet. 2020; 139(4):421-446.

PMID: 32020362 DOI: 10.1007/s00439-020-02114-w.

Sex-Specific Gene Expression Differences Are Evident in Human Embryonic Stem Cells and During In Vitro Differentiation of Human Placental Progenitor Cells.

Syrett C, Sierra I, Berry C, Beiting D, Anguera M Stem Cells Dev. 2018; 27(19):1360-1375.

PMID: 29993333 PMC: 6916123. DOI: 10.1089/scd.2018.0081.

Prostate cancer susceptibility and growth linked to Y chromosome genes.

Patel R, Khalifa A, Isali I, Shukla S Front Biosci (Elite Ed). 2018; 10(3):423-436.

PMID: 29293466 PMC: 6152832. DOI: 10.2741/e830.

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