The Role of Ubiquitin and the 26S Proteasome in Plant Abiotic Stress Signaling

Overview

Journal Front Plant Sci

Date 2014 May 6

PMID 24795732

Citations 141

Authors

Sophia L Stone

Affiliations

Soon will be listed here.

Abstract

Ubiquitin is a small, highly conserved, ubiquitously expressed eukaryotic protein with immensely important and diverse regulatory functions. A well-studied function of ubiquitin is its role in selective proteolysis by the ubiquitin-proteasome system (UPS). The UPS has emerged as an integral player in plant response and adaptation to environmental stresses such as drought, salinity, cold and nutrient deprivation. The UPS has also been shown to influence the production and signal transduction of stress-related hormones such as abscisic acid. Understanding UPS function has centered mainly on defining the role of E3 ubiquitin ligases, which are the substrate-recruiting component of the ubiquitination pathway. The recent identification of stress signaling/regulatory proteins that are the subject of ubiquitin-dependent degradation has increased our knowledge of how the UPS facilitates responses to adverse environmental conditions. A brief overview is provided on role of the UPS in modulating protein stability during abiotic stress signaling. E3 ubiquitin ligases for which stress-related substrate proteins have been identified are discussed.

Citing Articles

Identification of Quantitative Trait Loci and Analysis of Novel Candidate Genes for Resistance to False Smut of Rice Based on SSR Molecular Markers.

Fu R, Zhao L, Chen C, Wang J, Chen Y, Lu D Biomolecules. 2025; 15(2).

PMID: 40001489 PMC: 11852790. DOI: 10.3390/biom15020186.

Genome-Wide Analysis of HECT E3 Ligases Members in Provides Insights into the Role of in Plant Abiotic Stress Response.

Xie X, Hu S, Liu L, Pan H, Huang H, Cao X Int J Mol Sci. 2024; 25(22).

PMID: 39595966 PMC: 11593785. DOI: 10.3390/ijms252211896.

The Ubiquitin Tale: Current Strategies and Future Challenges.

Upadhyay A, Joshi V ACS Pharmacol Transl Sci. 2024; 7(9):2573-2587.

PMID: 39296276 PMC: 11406696. DOI: 10.1021/acsptsci.4c00278.

Hypoxia represses pattern-triggered immune responses in Arabidopsis.

Mooney B, Doorly C, Mantz M, Garcia P, Huesgen P, Graciet E Plant Physiol. 2024; 196(3):2064-2077.

PMID: 39158089 PMC: 11531839. DOI: 10.1093/plphys/kiae432.

Transcriptomic analyses provide molecular insight into the cold stress response of cold-tolerant alfalfa.

Pu X, Fu Y, Xu C, Li X, Wang W, De K BMC Plant Biol. 2024; 24(1):741.

PMID: 39095692 PMC: 11297790. DOI: 10.1186/s12870-024-05136-y.

References

Sato T, Maekawa S, Yasuda S, Domeki Y, Sueyoshi K, Fujiwara M . Identification of 14-3-3 proteins as a target of ATL31 ubiquitin ligase, a regulator of the C/N response in Arabidopsis. Plant J. 2011; 68(1):137-46. DOI: 10.1111/j.1365-313X.2011.04673.x. View

Bu Q, Li H, Zhao Q, Jiang H, Zhai Q, Zhang J . The Arabidopsis RING finger E3 ligase RHA2a is a novel positive regulator of abscisic acid signaling during seed germination and early seedling development. Plant Physiol. 2009; 150(1):463-81. PMC: 2675735. DOI: 10.1104/pp.109.135269. View

Luo H, Laluk K, Lai Z, Veronese P, Song F, Mengiste T . The Arabidopsis Botrytis Susceptible1 Interactor defines a subclass of RING E3 ligases that regulate pathogen and stress responses. Plant Physiol. 2010; 154(4):1766-82. PMC: 2996010. DOI: 10.1104/pp.110.163915. View

Nakasone M, Livnat-Levanon N, Glickman M, Cohen R, Fushman D . Mixed-linkage ubiquitin chains send mixed messages. Structure. 2013; 21(5):727-40. PMC: 3654000. DOI: 10.1016/j.str.2013.02.019. View

Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper J . SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell. 1996; 86(2):263-74. DOI: 10.1016/s0092-8674(00)80098-7. View

Stone S, Callis J . Ubiquitin ligases mediate growth and development by promoting protein death. Curr Opin Plant Biol. 2007; 10(6):624-32. DOI: 10.1016/j.pbi.2007.07.010. View

Li H, Jiang H, Bu Q, Zhao Q, Sun J, Xie Q . The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic acid signaling and drought response. Plant Physiol. 2011; 156(2):550-63. PMC: 3177258. DOI: 10.1104/pp.111.176214. View

Chen Z, Sun L . Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell. 2009; 33(3):275-86. DOI: 10.1016/j.molcel.2009.01.014. View

Lee J, Yoon H, Terzaghi W, Martinez C, Dai M, Li J . DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction. Plant Cell. 2010; 22(6):1716-32. PMC: 2910972. DOI: 10.1105/tpc.109.073783. View

10.

Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y . Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009; 324(5930):1068-71. PMC: 2827199. DOI: 10.1126/science.1173041. View

11.

Chen Y, Liu H, Stone S, Callis J . ABA and the ubiquitin E3 ligase KEEP ON GOING affect proteolysis of the Arabidopsis thaliana transcription factors ABF1 and ABF3. Plant J. 2013; 75(6):965-76. PMC: 3823012. DOI: 10.1111/tpj.12259. View

12.

Liu H, Stone S . E3 ubiquitin ligases and abscisic acid signaling. Plant Signal Behav. 2011; 6(3):344-8. PMC: 3142413. DOI: 10.4161/psb.6.3.13914. View

13.

Takano J, Noguchi K, Yasumori M, Kobayashi M, Gajdos Z, Miwa K . Arabidopsis boron transporter for xylem loading. Nature. 2002; 420(6913):337-40. DOI: 10.1038/nature01139. View

14.

Maekawa S, Sato T, Asada Y, Yasuda S, Yoshida M, Chiba Y . The Arabidopsis ubiquitin ligases ATL31 and ATL6 control the defense response as well as the carbon/nitrogen response. Plant Mol Biol. 2012; 79(3):217-27. DOI: 10.1007/s11103-012-9907-0. View

15.

Irigoyen M, Iniesto E, Rodriguez L, Puga M, Yanagawa Y, Pick E . Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell. 2014; 26(2):712-28. PMC: 3967035. DOI: 10.1105/tpc.113.122234. View

16.

Miwa K, Takano J, Fujiwara T . Improvement of seed yields under boron-limiting conditions through overexpression of BOR1, a boron transporter for xylem loading, in Arabidopsis thaliana. Plant J. 2006; 46(6):1084-91. DOI: 10.1111/j.1365-313X.2006.02763.x. View

17.

Coruzzi G, Bush D . Nitrogen and carbon nutrient and metabolite signaling in plants. Plant Physiol. 2001; 125(1):61-4. PMC: 1539326. DOI: 10.1104/pp.125.1.61. View

18.

Finkelstein R . Abscisic Acid synthesis and response. Arabidopsis Book. 2013; 11:e0166. PMC: 3833200. DOI: 10.1199/tab.0166. View

19.

Lazaro A, Valverde F, Pineiro M, Jarillo J . The Arabidopsis E3 ubiquitin ligase HOS1 negatively regulates CONSTANS abundance in the photoperiodic control of flowering. Plant Cell. 2012; 24(3):982-99. PMC: 3336113. DOI: 10.1105/tpc.110.081885. View

20.

Hotton S, Callis J . Regulation of cullin RING ligases. Annu Rev Plant Biol. 2008; 59:467-89. DOI: 10.1146/annurev.arplant.58.032806.104011. View