Anxiety- and Depression-like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson's Disease

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2014 May 6

PMID 24795584

Citations 55

Authors

Olga Lopatina

Toru Yoshihara

Tomoko Nishimura

Jing Zhong

Shirin Akther

Azam A K M Fakhrul

Mingkun Liang

Chiharu Higashida

Kohei Sumi

Kazumi Furuhara

Yuki Inahata

Jian-Jung Huang

Keita Koizumi

Shigeru Yokoyama

Takahiro Tsuji

Yulia Petugina

Andrei Sumarokov

Alla B Salmina

Koji Hashida

Yasuko Kitao

Osamu Hori

Masahide Asano

Yoji Kitamura

Takashi Kozaka

Kazuhiro Shiba

Fangfang Zhong

Min-Jue Xie

Makoto Sato

Katsuhiko Ishihara

Haruhiro Higashida

Affiliations

Soon will be listed here.

Abstract

CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.

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