A Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy Successfully Managed with Subcutaneous Octreotide Injection and Nocturnal Intravenous Glucose Supply

Overview

Journal Clin Pediatr Endocrinol

Specialty Pediatrics

Date 2014 May 3

PMID 24790349

Citations 3

Authors

Mari Murakami

Sotaro Mushiake

Hiroko Kashiwagi

Yuri Etani

Yoko Miyoshi

Keiichi Ozono

Affiliations

Soon will be listed here.

Abstract

Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is often resistant to medical therapy and is normally treated by subtotal pancreatectomy to avoid neurological complications. However, many problems after surgery, such as recurrence of hypoglycemia and diabetes mellitus, remain to be solved. This report concerns a case of PHHI that was resistant to octreotide or diazoxide alone but was successfully controlled with subcutaneous injection of octreotide in combination with nocturnal glucose infusion through central venous catheter. The patient exhibited natural remission of hyperinsulinism with age, and all treatment was ceased at the age of 4 yr. Growth and neurological development of the patient have been normal. This combined therapy can be a therapeutic option as a substitute for surgical solutions.

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