Impact of Sleep and Breathing in Infancy on Outcomes at Three Years of Age for Children with Cleft Lip And/or Palate

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2014 May 3

PMID 24790270

Citations 14

Authors

Courtney B Smith

Karen Walker

Nadia Badawi

Karen A Waters

Joanna E MacLean

Affiliations

Soon will be listed here.

Abstract

Study Objectives: To evaluate the relationship between sleep disordered breathing (SDB) in early infancy and outcomes at 3 years of age in children with cleft lip and/or palate (CL/P).

Design: Observational follow-up study.

Setting: Multidisciplinary CL/P clinic, tertiary centre.

Participants: Children with CL/P who participated in a study of sleep and breathing in infancy.

Measurements And Results: The families of 52 children were approached for this follow-up study. The children underwent neurocognitive (Bayley Scales of Infant and Toddler Development, Third Edition; BSID-III), quality of life (Infant/Toddler Quality of Life Questionnaire; ITQOL), and growth assessments at 3 years. The families of 33 children (66%) completed follow-up at 36.7 ± 1.4 months. The apnea-hypopnea index (AHI) in infancy was 23.9 ± 18.0 events/h. Mean group BSID-III scores fell within the standardized normal range (10 ± 3) for all domains; however, language scores were lower than control children. Quality of life scores and growth parameter z-scores were similar to published control data. PSG variables in infancy showed significant relationships with outcomes at 3 years of age; lower percentage of AS/REM sleep was associated with lower cognition score; more obstructive events were associated with lower global behavior ITQOL score; and higher number of respiratory events in infancy was associated with lower weight z-score.

Conclusion: Neurocognition, quality of life, and growth measures from children with CL/P fall within a normal range; however, scores in the language domain are lower than controls. Sleep and respiratory elements of SDB in infancy appear to modify these outcomes at 3 years of age.

Citing Articles

Respiratory and Neurodevelopmental Outcomes at 3 Years of Age of Neonates Diagnosed with Sleep-Disordered Breathing.

Mehta B, Waters K, Fitzgerald D, Badawi N J Clin Med. 2024; 13(18).

PMID: 39337016 PMC: 11432704. DOI: 10.3390/jcm13185527.

Developmental Risk for Infants with Cleft Lip with or Without Cleft Palate Based on Caregiver-Proxy Reports.

Kapp-Simon K, Albert M, Edwards T, Jones S, Crilly Bellucci C, Rosenberg J Cleft Palate Craniofac J. 2024; :10556656231225304.

PMID: 38196373 PMC: 11231059. DOI: 10.1177/10556656231225304.

Predictive Power of Oxygen Desaturation Index (ODI) and Apnea-Hypopnea Index (AHI) in Detecting Long-Term Neurocognitive and Psychosocial Outcomes of Sleep-Disordered Breathing in Children: A Questionnaire-Based Study.

Zaffanello M, Ferrante G, Zoccante L, Ciceri M, Nosetti L, Tenero L J Clin Med. 2023; 12(9).

PMID: 37176501 PMC: 10179379. DOI: 10.3390/jcm12093060.

Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate.

Kuhlmann E, van der Plas E, Axelson E, Conrad A Dev Neuropsychol. 2021; 46(4):314-326.

PMID: 34348063 PMC: 8814052. DOI: 10.1080/87565641.2021.1946691.

Early Communication Behaviors in Infants With Cleft Palate With and Without Robin Sequence: A Preliminary Study.

van Eeden S, Wren Y, McKean C, Stringer H Cleft Palate Craniofac J. 2021; 59(8):984-994.

PMID: 34259062 PMC: 9272514. DOI: 10.1177/10556656211031877.

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