The Brain Melanocortin System, Sympathetic Control, and Obesity Hypertension

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2014 May 3

PMID 24789984

Citations 21

Authors

Alexandre A da Silva

Jussara M do Carmo

Zhen Wang

John E Hall

Affiliations

Soon will be listed here.

Abstract

Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential mechanisms by which the brain melanocortin system modulates metabolic and cardiovascular functions.

Citing Articles

Targeting the Brain Leptin-Melanocortin Pathway to Treat Heart Failure.

Omoto A, do Carmo J, Mouton A, Wang Z, Li X, Spitz R Curr Hypertens Rep. 2024; 27(1):2.

PMID: 39612121 PMC: 11607000. DOI: 10.1007/s11906-024-01318-z.

Mechanisms and treatment of obesity-related hypertension-Part 1: Mechanisms.

Parvanova A, Reseghetti E, Abbate M, Ruggenenti P Clin Kidney J. 2024; 17(1):sfad282.

PMID: 38186879 PMC: 10768772. DOI: 10.1093/ckj/sfad282.

Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions.

Copperi F, Kim J, Diano S Front Physiol. 2021; 12:725709.

PMID: 34512392 PMC: 8424695. DOI: 10.3389/fphys.2021.725709.

Leptin and Melanocortin Signaling Mediates Hypertension in Offspring From Female Rabbits Fed a High-Fat Diet During Gestation and Lactation.

Lim K, Burke S, Marques F, Jackson K, Gueguen C, Sata Y Front Physiol. 2021; 12:693157.

PMID: 34248679 PMC: 8264761. DOI: 10.3389/fphys.2021.693157.

Obesity, kidney dysfunction, and inflammation: interactions in hypertension.

Hall J, Mouton A, da Silva A, Omoto A, Wang Z, Li X Cardiovasc Res. 2020; 117(8):1859-1876.

PMID: 33258945 PMC: 8262632. DOI: 10.1093/cvr/cvaa336.

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