Combined Radiofrequency Ablation and Ethanol Injection with a Multipronged Needle for the Treatment of Medium and Large Hepatocellular Carcinoma

Overview

Journal Eur Radiol

Specialty Radiology

Date 2014 May 3

PMID 24788036

Citations 9

Authors

Guangliang Huang

Manxia Lin

Xiaoyan Xie

Baoxian Liu

Zuofeng Xu

Riccardo Lencioni

Mingde Lu

Ming Kuang

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the efficacy and safety of combined radiofrequency ablation (RFA) and ethanol injection with a multipronged needle in the treatment of medium (3.1-5.0 cm) and large (5.1-7.0 cm) hepatocellular carcinoma (HCC).

Methods: A total of 65 patients with 67 HCC nodules were enrolled in this prospective study. All of them received the treatment of combined RFA and multipronged ethanol injection percutaneously.

Results: The average volume of injected ethanol was 14.4 ± 4.1 ml (range, 9-30 ml). The average number of RFA electrode insertions was 1.7 ± 0.8 (range, 1-4). The rate of initial local complete response (CR) was 94.0 % (63/67). After additional treatment, technical success was achieved in all HCC nodules. There were no treatment-related deaths, and major complications were observed in 3 (4.6%) patients. After a mean follow-up of 20.0 ± 7.6 months, local tumour progression was observed in 10 (10/67, 14.9%) tumours, whereas distant recurrence developed in 32 (32/65, 49.2%) patients. The 1-year and 2-year survival rates were 93.1% and 88.1%, respectively.

Conclusion: The combination of RFA and multipronged ethanol injection in the treatment of medium and large HCC is safe and effective with a high rate of local tumour control.

Key Points: • Combined radiofrequency ablation and multipronged ethanol injection is a new therapeutic strategy • Treatment is safe and effective for medium and large hepatocellular carcinoma (HCC) • A multipronged needle allows for a homogeneous ethanol distribution.

Citing Articles

Determining the Relationship between Delivery Parameters and Ablation Distribution for Novel Gel Ethanol Percutaneous Therapy in Ex Vivo Swine Liver.

Chelales E, von Windheim K, Banipal A, Siebeneck E, Benham C, Nief C Polymers (Basel). 2024; 16(7).

PMID: 38611255 PMC: 11013462. DOI: 10.3390/polym16070997.

Efficacy and Safety of Microwave Ablation Assisted by Ultrasound Fusion Imaging for Primary and Secondary Liver Cancers with a Diameter of 3-7 Cm.

Yang J, Liang S, Liu H, Hu C, Guan S, Kang H J Hepatocell Carcinoma. 2023; 10:1839-1848.

PMID: 37873028 PMC: 10590584. DOI: 10.2147/JHC.S424009.

Long-term outcomes of combined radiofrequency ablation and multipronged ethanol ablation for the treatment of unfavorable hepatocellular carcinoma.

Liu M, Li X, Zhang X, Kuang M, Xie X, Huang G Diagn Interv Radiol. 2023; 29(2):342-349.

PMID: 36987999 PMC: 10679715. DOI: 10.4274/dir.2022.22832.

Application of ablative therapy for intrahepatic recurrent hepatocellular carcinoma following hepatectomy.

Cong R, Ma X, Wang S, Feng B, Cai W, Chen Z World J Gastrointest Surg. 2023; 15(1):9-18.

PMID: 36741068 PMC: 9896493. DOI: 10.4240/wjgs.v15.i1.9.

Predictive factors of treatment outcomes after percutaneous ablation of hepatocellular carcinoma in the caudate lobe: a retrospective study.

Liu B, Long J, Wang W, Huang T, Xie X, Chen S BMC Cancer. 2019; 19(1):699.

PMID: 31311502 PMC: 6636011. DOI: 10.1186/s12885-019-5881-0.

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