Natural Compounds As Next-generation Herbicides

Overview

Journal Plant Physiol

Specialty Physiology

Date 2014 May 3

PMID 24784133

Citations 74

Authors

Franck E Dayan

Stephen O Duke

Affiliations

Soon will be listed here.

Abstract

Herbicides with new modes of action (MOAs) are badly needed due to the rapidly evolving resistance to commercial herbicides, but a new MOA has not been introduced in over 20 years. The greatest pest management challenge for organic agriculture is the lack of effective natural product herbicides. The structural diversity and evolved biological activity of natural phytotoxins offer opportunities for the development of both directly used natural compounds and synthetic herbicides with new target sites based on the structures of natural phytotoxins. Natural phytotoxins are also a source for the discovery of new herbicide target sites that can serve as the focus of traditional herbicide discovery efforts. There are many examples of strong natural phytotoxins with MOAs other than those used by commercial herbicides, which indicates that there are molecular targets of herbicides that can be added to the current repertoire of commercial herbicide MOAs.

Citing Articles

Label free quantitative proteomic analysis reveals the physiological and biochemical responses of Arabidopsis thaliana to cinnamon essential oil.

Kaab S, Martin M, Degand H, Foncoux B, Morsomme P, Jijakli M Sci Rep. 2025; 15(1):6156.

PMID: 39979395 PMC: 11842708. DOI: 10.1038/s41598-025-89368-4.

Advances on Bioactive Metabolites with Potential for the Biocontrol of Plant Pathogenic Bacteria.

Reveglia P, Corso G, Evidente A Pathogens. 2024; 13(11).

PMID: 39599553 PMC: 11597488. DOI: 10.3390/pathogens13111000.

Evaluation of herbicidal potential of Siderophores produced by Amycolatopsis lurida strain 407.

Eigharlou M, Javidpoor S, Mohammadi A, Khelghatibana F, Nami Y, Mamani L Sci Rep. 2024; 14(1):26212.

PMID: 39482417 PMC: 11528001. DOI: 10.1038/s41598-024-77843-3.

Enhanced Antioxidant, Antifungal, and Herbicidal Activities through Bioconversion of Diosgenin by .

Hernandez-Guzman C, Hernandez-Montiel L, Velazquez-Lizarraga A, Rios-Gonzalez L, Huerta-Ochoa S, Cervantes-Guicho V Plants (Basel). 2024; 13(18).

PMID: 39339605 PMC: 11434977. DOI: 10.3390/plants13182629.

Natural Rubrolides and Their Synthetic Congeners as Inhibitors of the Photosynthetic Electron Transport Chain.

Karak M, Acosta J, Cortez-Hernandez H, Cardona J, Forlani G, Barbosa L J Nat Prod. 2024; 87(9):2272-2280.

PMID: 39240232 PMC: 11443480. DOI: 10.1021/acs.jnatprod.4c00714.

References

Lowther W, Matthews B . Metalloaminopeptidases: common functional themes in disparate structural surroundings. Chem Rev. 2002; 102(12):4581-608. DOI: 10.1021/cr0101757. View

Daub M . Peroxidation of tobacco membrane lipids by the photosensitizing toxin, cercosporin. Plant Physiol. 1982; 69(6):1361-4. PMC: 426419. DOI: 10.1104/pp.69.6.1361. View

Okazaki S, Sugawara M, Yuhashi K, Minamisawa K . Rhizobitoxine-induced chlorosis occurs in coincidence with methionine deficiency in soybeans. Ann Bot. 2007; 100(1):55-9. PMC: 2735301. DOI: 10.1093/aob/mcm087. View

Daub M, Hangarter R . Light-induced production of singlet oxygen and superoxide by the fungal toxin, cercosporin. Plant Physiol. 1983; 73(3):855-7. PMC: 1066561. DOI: 10.1104/pp.73.3.855. View

Zheng W, Zhai Q, Sun J, Li C, Zhang L, Li H . Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis. Plant Physiol. 2006; 141(4):1400-13. PMC: 1533914. DOI: 10.1104/pp.106.080390. View

Flagel L, Wendel J . Gene duplication and evolutionary novelty in plants. New Phytol. 2009; 183(3):557-564. DOI: 10.1111/j.1469-8137.2009.02923.x. View

Norris S, Barrette T, Dellapenna D . Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. Plant Cell. 1995; 7(12):2139-49. PMC: 161068. DOI: 10.1105/tpc.7.12.2139. View

Lukens J, Mathews D, Durbin R . Effect of tagetitoxin on the levels of ribulose 1,5-bisphosphate carboxylase, ribosomes, and RNA in plastids of wheat leaves. Plant Physiol. 1987; 84(3):808-13. PMC: 1056674. DOI: 10.1104/pp.84.3.808. View

Moore R, Purugganan M . The evolutionary dynamics of plant duplicate genes. Curr Opin Plant Biol. 2005; 8(2):122-8. DOI: 10.1016/j.pbi.2004.12.001. View

10.

Owens D, Nanayakkara N, Dayan F . In planta mechanism of action of leptospermone: impact of its physico-chemical properties on uptake, translocation, and metabolism. J Chem Ecol. 2013; 39(2):262-70. DOI: 10.1007/s10886-013-0237-8. View

11.

Clifford Gerwick B, Sparks T . Natural products for pest control: an analysis of their role, value and future. Pest Manag Sci. 2014; 70(8):1169-85. DOI: 10.1002/ps.3744. View

12.

Grossmann K, Hutzler J, Tresch S, Christiansen N, Looser R, Ehrhardt T . On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase. Pest Manag Sci. 2011; 68(3):482-92. DOI: 10.1002/ps.2319. View

13.

Oracz K, Voegele A, Tarkowska D, Jacquemoud D, Tureckova V, Urbanova T . Myrigalone A inhibits Lepidium sativum seed germination by interference with gibberellin metabolism and apoplastic superoxide production required for embryo extension growth and endosperm rupture. Plant Cell Physiol. 2011; 53(1):81-95. DOI: 10.1093/pcp/pcr124. View

14.

Bajsa J, Pan Z, Duke S . Transcriptional responses to cantharidin, a protein phosphatase inhibitor, in Arabidopsis thaliana reveal the involvement of multiple signal transduction pathways. Physiol Plant. 2011; 143(2):188-205. DOI: 10.1111/j.1399-3054.2011.01494.x. View

15.

Cantrell C, Dayan F, Duke S . Natural products as sources for new pesticides. J Nat Prod. 2012; 75(6):1231-42. DOI: 10.1021/np300024u. View

16.

Hoober J, Kahn A, Ash D, Gough S, Kannangara C . Biosynthesis of delta-aminolevulinate in greening barley leaves. IX. Structure of the substrate, mode of gabaculine inhibition, and the catalytic mechanism of glutamate 1-semialdehyde aminotransferase. Carlsberg Res Commun. 1988; 53(1):11-25. DOI: 10.1007/BF02908411. View

17.

Omura S, Murata M, Imamura N, Iwai Y, Tanaka H, Furusaki A . Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity. J Antibiot (Tokyo). 1984; 37(11):1324-32. DOI: 10.7164/antibiotics.37.1324. View

18.

Halloin J, de Zoeten G, Walker J . The effects of tentoxin on chlorophyll synthesis and plastid structure in cucumber and cabbage. Plant Physiol. 1970; 45(3):310-4. PMC: 396402. DOI: 10.1104/pp.45.3.310. View

19.

Duke S . Why have no new herbicide modes of action appeared in recent years?. Pest Manag Sci. 2011; 68(4):505-12. DOI: 10.1002/ps.2333. View

20.

Meeley R, Walton J . Enzymatic Detoxification of HC-toxin, the Host-Selective Cyclic Peptide from Cochliobolus carbonum. Plant Physiol. 1991; 97(3):1080-6. PMC: 1081125. DOI: 10.1104/pp.97.3.1080. View