Gr-1+CD11b+ Cells Facilitate Lewis Lung Cancer Recurrence by Enhancing Neovasculature After Local Irradiation

Overview

Journal Sci Rep

Specialty Science

Date 2014 Apr 30

PMID 24776637

Citations 9

Authors

Tao Liu

Congying Xie

Hong Ma

Sheng Zhang

Yicheng Liang

Liangliang Shi

Dandan Yu

Yiming Feng

Tao Zhang

Gang Wu

Affiliations

Soon will be listed here.

Abstract

Studies have shown that bone marrow-derived cells play an important role in tumor recurrence after chemotherapy and radiotherapy. In this study, we examined the relationship between the accumulation of Gr-1+CD11b+ cells and tumor recurrence after irradiation in tumor-bearing mice. By transplanting bone marrow cells into whole body-irradiated mice depleted of bone marrow, we assessed the role of Gr-1+CD11b+ cells in lung carcinoma models after local irradiation (LI). 20 Gy local irradiation could recruit CD11b+CXCR4+ cells into the irradiated tissues, and the recruited CD11b+CXCR4+ cells could promote tumor recurrence. Further 6 Gy whole body irradiation (WBI6Gy) could decrease tumor recurrence by inhibiting the accumulation of Gr-1+CD11b+ cells and then suppressing tumor vasculogenesis and angiogenesis. Our results suggest that the accumulation of CD11b+Gr-1+ cells promote tumor re-growth after local irradiation by enhancing tumor neovascularization, and low dose of whole body irradiation or irradiation of enlarged spleen may provide a new alternative for anti-angiogenesis therapies.

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