Enhancing the Efficacy of Mesenchymal Stem Cell Therapy

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2014 Apr 29

PMID 24772236

Citations 49

Authors

Michalis Mastri

Huey Lin

Techung Lee

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cell (MSC) therapy is entering a challenging phase after completion of many preclinical and clinical trials. Among the major hurdles encountered in MSC therapy are inconsistent stem cell potency, poor cell engraftment and survival, and age/disease-related host tissue impairment. The recognition that MSCs primarily mediate therapeutic benefits through paracrine mechanisms independent of cell differentiation provides a promising framework for enhancing stem cell potency and therapeutic benefits. Several MSC priming approaches are highlighted, which will likely allow us to harness the full potential of adult stem cells for their future routine clinical use.

Citing Articles

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References

Wu G, Rana J, Wykrzykowska J, Du Z, Ke Q, Kang P . Exercise-induced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction. Am J Physiol Heart Circ Physiol. 2008; 296(2):H389-95. PMC: 2643900. DOI: 10.1152/ajpheart.01393.2007. View

Tyndall A, Walker U, Cope A, Dazzi F, De Bari C, Fibbe W . Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Res Ther. 2007; 9(1):301. PMC: 1860056. DOI: 10.1186/ar2103. View

Izadpanah R, Kaushal D, Kriedt C, Tsien F, Patel B, Dufour J . Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. Cancer Res. 2008; 68(11):4229-38. PMC: 2713721. DOI: 10.1158/0008-5472.CAN-07-5272. View

Sedivy J . Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc Natl Acad Sci U S A. 1998; 95(16):9078-81. PMC: 33878. DOI: 10.1073/pnas.95.16.9078. View

Allison M . Genzyme backs Osiris, despite Prochymal flop. Nat Biotechnol. 2009; 27(11):966-7. DOI: 10.1038/nbt1109-966. View

Hare J, Traverse J, Henry T, Dib N, Strumpf R, Schulman S . A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009; 54(24):2277-86. PMC: 3580848. DOI: 10.1016/j.jacc.2009.06.055. View

Brown J, Wang H, Hajishengallis G, Martin M . TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res. 2010; 90(4):417-27. PMC: 3075579. DOI: 10.1177/0022034510381264. View

Lee T . Host tissue response in stem cell therapy. World J Stem Cells. 2010; 2(4):61-6. PMC: 2964154. DOI: 10.4252/wjsc.v2.i4.61. View

Jiang R, Han Z, Zhuo G, Qu X, Li X, Wang X . Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. Front Med. 2011; 5(1):94-100. DOI: 10.1007/s11684-011-0116-z. View

10.

Phinney D, Kopen G, Righter W, Webster S, Tremain N, Prockop D . Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem. 1999; 75(3):424-36. View

11.

Lai T, Fong Y, Fu W, Yang R, Tang C . Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells. J Cell Physiol. 2008; 218(2):334-42. DOI: 10.1002/jcp.21601. View

12.

Hahn J, Cho H, Kang H, Kim T, Kim M, Chung J . Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol. 2008; 51(9):933-43. DOI: 10.1016/j.jacc.2007.11.040. View

13.

Liu X, Wang J, Ogle M, Wei L . Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival. J Cell Biochem. 2009; 106(5):903-11. DOI: 10.1002/jcb.22064. View

14.

Hill J, Zalos G, Halcox J, Schenke W, Waclawiw M, Quyyumi A . Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003; 348(7):593-600. DOI: 10.1056/NEJMoa022287. View

15.

Thompson P, Buchner D, Pina I, Balady G, Williams M, Marcus B . Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition,.... Circulation. 2003; 107(24):3109-16. DOI: 10.1161/01.CIR.0000075572.40158.77. View

16.

Rissanen T, Vajanto I, Hiltunen M, Rutanen J, Kettunen M, Niemi M . Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. Am J Pathol. 2002; 160(4):1393-403. PMC: 1867222. DOI: 10.1016/S0002-9440(10)62566-7. View

17.

Phillips R, Mestas J, Gharaee-Kermani M, Burdick M, Sica A, Belperio J . Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of.... J Biol Chem. 2005; 280(23):22473-81. DOI: 10.1074/jbc.M500963200. View

18.

Pattappa G, Thorpe S, Jegard N, Heywood H, de Bruijn J, Lee D . Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells. Tissue Eng Part C Methods. 2012; 19(1):68-79. DOI: 10.1089/ten.TEC.2011.0734. View

19.

Zvibel I, Smets F, Soriano H . Anoikis: roadblock to cell transplantation?. Cell Transplant. 2003; 11(7):621-30. DOI: 10.3727/000000002783985404. View

20.

Sasaki K, Heeschen C, Aicher A, Ziebart T, Honold J, Urbich C . Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A. 2006; 103(39):14537-41. PMC: 1599995. DOI: 10.1073/pnas.0604144103. View