Enhancement and Suppression of DTH Reactivity to Rauscher Murine Leukaemia Virus Induced Tumour Cell Lines

Overview

Journal Br J Cancer

Specialty Oncology

Date 1989 Sep 1

PMID 2477052

Citations 2

Authors

A C Knulst

D Berends

C Bazuin

H C van Rooij

N J de Both

R Benner

Affiliations

Soon will be listed here.

Abstract

Delayed-type hypersensitivity (DTH) to Rauscher murine leukaemia virus (R-MuLV) encoded or induced determinants was induced in mice by three syngeneic R-MuLV-induced tumour cell lines, i.e. a myeloid tumour, RMB-1, an erythroid tumour, RED-1, and a lymphoid tumour, RLD-1. DTH to subcutaneously (s.c.) administered RMB-1 cells appeared on day 4, with a maximum DTH response on day 6 or 7. The induction of DTH could be prevented by intravenous (i.v.) pre-immunisation with R-MuLV-induced tumour cells several days before the s.c. immunisation. The three R-MuLV-induced tumour cell lines showed cross-reactivity in the DTH assay, whereas no cross-reactivity was found with syngeneic WEHI-3 cells. This indicates that the three R-MuLV-induced tumour cell lines share a virally encoded or induced antigenic determinant, which activates T-cells. When the RMB-1 cells used for immunisation had been cultured in medium supplemented with interferon-gamma (IFN-gamma), the subsequent DTH response was increased. This coincided with an increased expression of the R-MuLV-specific antigenic determinants on RMB-1 cells as demonstrated by Scatchard analysis. Furthermore, IFN-gamma increased the MHC class I antigen expression on RMB-1 cells, whereas the class II antigen expression remained undetectable.

Citing Articles

Factors influencing antibody-mediated cytotoxicity during the immunotherapy of Rauscher-virus-induced myeloid leukemic cells.

Berends D, van der Kwast T, de Both N, Mulder P Cancer Immunol Immunother. 1989; 28(2):123-30.

PMID: 2783887 PMC: 11038669. DOI: 10.1007/BF00199112.

Potentiation of delayed-type hypersensitivity response to syngeneic tumors in mice prevaccinated with cells modified by hydrostatic pressure and crosslinking.

Ramakrishna V, Shinitzky M Cancer Immunol Immunother. 1991; 33(1):1-8.

PMID: 2021954 PMC: 11038986. DOI: 10.1007/BF01742520.

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