Pharmacological Investigation of Acute Cellular Accumulation in Immunological Air Pouch Inflammation

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1989 Aug 1

PMID 2476924

Citations 1

Authors

P Hambleton

P Miller

Affiliations

Soon will be listed here.

Abstract

Immunologically-mediated cellular accumulation was measured 24 hours after antigenic challenge using a rat subcutaneous air pouch model. This response was inhibited by treatment with prednisolone, colchicine, anti-thymocyte serum and systemic antigen. In contrast, administration of a range of other pharmacological and clinically active agents had little effect. The profile of inhibitory activity suggested that this response was mainly due to delayed type hypersensitivity with little anaphylactic or Arthus-type component.

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References

Dunn C, Miller S . The effects of cyclosporin A on leucocyte infiltration and procoagulant activity in the mouse delayed hypersensitivity response in vivo. Int J Immunopharmacol. 1986; 8(6):635-43. DOI: 10.1016/0192-0561(86)90036-6. View

Smith R, Iden S, Rohloff N . A model of Arthus pleurisy: modulation by various pharmacologic and therapeutic agents. Clin Immunol Immunopathol. 1983; 26(1):24-34. DOI: 10.1016/0090-1229(83)90170-8. View

Dieppe P, Willoughby D, Huskisson E, ARRIGONI-MARTELLI E . Pertussis vaccine pleurisy: a model of delayed hypersensitivity. Agents Actions. 1976; 6(5):618-21. DOI: 10.1007/BF01971580. View

Willoughby D, COOTE E, Turk J . Complement in acute inflammation. J Pathol. 1969; 97(2):295-305. DOI: 10.1002/path.1710970215. View

Johnson W, Muirhead K, Meunier P, Votta B, Schmitt T, Dimartino M . Macrophage activation in rat models of inflammation and arthritis. Systemic activation precedes arthritis induction and progression. Arthritis Rheum. 1986; 29(9):1122-30. DOI: 10.1002/art.1780290910. View

Ohuchi K, Watanabe M, Levine L . Arachidonate metabolites in acute and chronic allergic air pouch inflammation in rats and the anti-inflammatory effects of indomethacin and dexamethasone. Int Arch Allergy Appl Immunol. 1984; 75(2):157-63. DOI: 10.1159/000233607. View

Sin Y, Sedgwick A, Willoughby D . Immune inflammation in newly developing facsimile synovia. Int Arch Allergy Appl Immunol. 1984; 73(3):286-7. DOI: 10.1159/000233484. View

Di Rosa M, Calignano A, Carnuccio R, Ialenti A, Sautebin L . Multiple control of inflammation by glucocorticoids. Agents Actions. 1986; 17(3-4):284-9. DOI: 10.1007/BF01982621. View

Sedgwick A, Hooke R, Lees P, May S . Modulation of lymphocyte activating factor activity (interleukin 1 like activity) and acute phase proteins in pertussis-induced air pouch inflammation by muramyl dipeptide. Agents Actions. 1987; 21(1-2):113-20. DOI: 10.1007/BF01974931. View

10.

Fletcher D, Osinga D, Bonney R . Role of polymorphonuclear leukocytes in connective tissue breakdown during the reverse passive Arthus reaction. Biochem Pharmacol. 1986; 35(15):2601-6. DOI: 10.1016/0006-2952(86)90059-6. View

11.

Sedgwick A, Moore A, Al-Duaij A, Edwards J, Willoughby D . The immune response to pertussis in the 6-day air pouch: a model of chronic synovitis. Br J Exp Pathol. 1985; 66(4):455-64. PMC: 2041101. View

12.

Katori M, Ikeda K, Harada Y, Uchida Y, Tanaka K, Oh-ishi S . A possible role of prostaglandins and bradykinin as a trigger of exudation in carrageenin-induced rat pleurisy. Agents Actions. 1978; 8(1-2):108-12. DOI: 10.1007/BF01972411. View

13.

Mjornstedt L, Olausson M, Hedman L, Lindholm L, Brynger H . Induction of long-term heart allograft survival in the rat by rabbit ATG. Int Arch Allergy Appl Immunol. 1984; 74(3):193-9. DOI: 10.1159/000233542. View

14.

Hambleton P, Miller P . Studies on immunological air pouch inflammation in the rat. Int Arch Allergy Appl Immunol. 1988; 87(1):70-5. DOI: 10.1159/000234651. View

15.

Bramm E, Binderup L, ARRIGONI-MARTELLI E . Delayed hypersensitivity to tuberculin in rats: effects of antirheumatic drugs. Acta Pharmacol Toxicol (Copenh). 1979; 44(1):75-80. DOI: 10.1111/j.1600-0773.1979.tb02297.x. View

16.

Galli S, Dvorak A . What do mast cells have to do with delayed hypersensitivity?. Lab Invest. 1984; 50(4):365-8. View

17.

Miyasaka K, Mikami T . Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats. Eur J Pharmacol. 1982; 77(4):229-36. DOI: 10.1016/0014-2999(82)90123-6. View

18.

Hirasawa N, Ohuchi K, Watanabe M, Tsurufuji S . Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. J Pharmacol Exp Ther. 1987; 241(3):967-73. View

19.

Blackham A, Woods A . The effect of some anti-rheumatic agents on tuberculin pleurisy in the guinea-pig [proceedings]. Br J Pharmacol. 1979; 67(3):447P-448P. PMC: 2043975. View

20.

Berkenkopf J, Weichman B . Differential effects of anti-inflammatory drugs on fluid accumulation and cellular infiltration in reverse passive arthus pleurisy and carrageenan pleurisy in rats. Pharmacology. 1987; 34(6):309-25. DOI: 10.1159/000138285. View