Up-to-date Approach to Manage Keloids and Hypertrophic Scars: a Useful Guide

Overview

Journal Burns

Publisher Elsevier

Date 2014 Apr 29

PMID 24767715

Citations 135

Authors

Anna I Arno

Gerd G Gauglitz

Juan P Barret

Marc G Jeschke

Affiliations

Soon will be listed here.

Abstract

Keloids and hypertrophic scars occur anywhere from 30 to 90% of patients, and are characterized by pathologically excessive dermal fibrosis and aberrant wound healing. Both entities have different clinical and histochemical characteristics, and unfortunately still represent a great challenge for clinicians due to lack of efficacious treatments. Current advances in molecular biology and genetics reveal new preventive and therapeutical options which represent a hope to manage this highly prevalent, chronic and disabling problem, with long-term beneficial outcomes and improvement of quality of life. While we wait for these translational clinical products to be marketed, however, it is imperative to know the basics of the currently existing wide array of strategies to deal with excessive scars: from the classical corticotherapy, to the most recent botulinum toxin and lasers. The main aim of this review paper is to offer a useful up-to-date guideline to prevent and treat keloids and hypertrophic scars.

Citing Articles

The Combination of Tunnel Shaped Excision with Radiotherapy and Injection of Type A Botulinum Toxin in the Treatment of Auricular Keloids.

Hou J, Liu C Aesthetic Plast Surg. 2025; .

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Scoping review for pain mitigation during intralesional injections of corticosteroid for hypertrophic scar and keloid treatment.

Mardhiah J, Halim A, Heng S, Saipolamin A BMJ Open. 2025; 15(2):e092800.

PMID: 40010838 PMC: 11865806. DOI: 10.1136/bmjopen-2024-092800.

Comparing the Efficacy of Triamcinolone Acetonide Versus Bleomycin in Hypertrophic Scars in Burn Patients: A Clinical Trial.

Farokh Forghani S, Sobouti B, Shahbazi A, Ghavami Y, Ghanooni P, Vaghardoost R Med J Islam Repub Iran. 2025; 38():111.

PMID: 39781328 PMC: 11707708. DOI: 10.47176/mjiri.38.111.

Long-Term Outcome of Anterior Chest Keloid Excision Using Intercostal Artery Perforator Propeller Flaps.

Zhang Y, Wang C, Lyu D, Wang D, Zhou R Aesthetic Plast Surg. 2024; .

PMID: 39627332 DOI: 10.1007/s00266-024-04574-1.

The Relationship between Health-Related Quality of Life, Subjective Scar Estimation, and Activity Performance in Adult Burn Patients 6 and 12 Months after Injury.

Enblom S, Sundin E, Gune G, Aspling N, Huss F Eur Burn J. 2024; 3(4):486-492.

PMID: 39600016 PMC: 11571816. DOI: 10.3390/ebj3040042.

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