In Vitro IgM and IgM Rheumatoid Factor Production in Response to Staphylococcus Aureus Cowan I and Pokeweed Mitogen: the Contribution of CD5+ (Leu 1) B Cells

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1989 Aug 1

PMID 2476269

Citations 3

Authors

J Karsh

R Goldstein

A I Lazarovits

Affiliations

Soon will be listed here.

Abstract

The relation between the percentage of circulating CD5+ CD20+ B cells and the ability to synthesize IgM and IgM rheumatoid factor (RF) in vitro in response to pokeweed mitogen (PWM) and Staphylococcus aureus Cowan I (SAC) was assessed in 21 healthy controls. CD5+ CD20+ cells ranged from 7.3 to 19.9% of total CD20+ B cells. By Spearman's rank correlation, there was an inverse relation between the percentage of CD5+ CD20+ B cells and IgM production in response to PWM (rs = -0.452, p less than 0.05) and a direct correlation with RF production in response to SAC (rs = 0.450, P less than 0.05). The percentage of CD5+ CD20+ B cells was not related to any serologic HLA-A, B, C or D antigen. Healthy individuals may be predisposed to producing IgM or autoantibodies based on the percentage of circulating CD5+ Cd20+ B cells.

Citing Articles

Increased numbers of CD5+ B cells and T cell receptor (TCR) gamma delta+ T cells are associated with younger age of onset in rheumatoid arthritis (RA).

Hassan J, Yanni G, Hegarty V, Feighery C, Bresnihan B, Whelan A Clin Exp Immunol. 1996; 103(3):353-6.

PMID: 8608631 PMC: 2200359. DOI: 10.1111/j.1365-2249.1996.tb08287.x.

Induction of IgM and IgM-rheumatoid factor synthesis in vitro by indomethacin.

Hassan J, Whelan A, Bresnihan B, Feighery C Rheumatol Int. 1991; 10(6):235-9.

PMID: 2041981 DOI: 10.1007/BF02274885.

In vitro IgG rheumatoid factor production by CD5-negative murine B cells in response to immune complexes of lipopolysaccharide.

Taguchi H, Kanoh M, Takubo N, Kadota S, Kanazawa K, Shibata T Clin Exp Immunol. 1990; 82(1):128-32.

PMID: 1698578 PMC: 1535172. DOI: 10.1111/j.1365-2249.1990.tb05415.x.

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