Development and Evaluation of Ca(+ 2) Ion Cross-linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique

Overview

Journal AAPS PharmSciTech

Publisher Springer

Specialty Pharmacology

Date 2014 Apr 25

PMID 24760471

Citations 2

Authors

Siddhartha Maity

Biswanath Sa

Affiliations

Soon will be listed here.

Abstract

The objective of this work was to study the release behavior of prednisolone from calcium-cross-linked carboxymethyl xanthan gum (CMXG) tablets in dissolution medium having different pH values prevailing in the gastrointestinal lumen. Xanthan gum (XG) was derivatized to CMXG which was then cross-linked in situ with Ca(+2) ion during wet massing step of tablet preparation. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry studies did not show any drug-polymer interaction although the drug underwent solid-state transformation during compression as evident from X-ray diffraction analysis. In vitro release study demonstrated that increase in the amount of Ca(+2) ion decreased the drug release, and beyond a certain amount, the drug release increased. While increase in both drug load and tablet crushing strength decreased the drug release, increase in exposure time in acid solution of pH 1.2 increased the overall release of the drug. The mechanism of drug release was non-Fickian/anomalous. The results indicated that variation in the amount of Ca(+2) ion can modulate the drug release from CMXG matrix tablets as needed.

Citing Articles

In Vitro and In Vivo Correlation of Colon-Targeted Compression-Coated Tablets.

Maity S, Kundu A, Karmakar S, Sa B J Pharm (Cairo). 2016; 2016:5742967.

PMID: 26989562 PMC: 4773564. DOI: 10.1155/2016/5742967.

Compression-Coated Tablet for Colon Targeting: Impact of Coating and Core Materials on Drug Release.

Maity S, Sa B AAPS PharmSciTech. 2015; 17(2):504-15.

PMID: 26271189 PMC: 4984885. DOI: 10.1208/s12249-015-0359-0.

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