The Maastricht Study: an Extensive Phenotyping Study on Determinants of Type 2 Diabetes, Its Complications and Its Comorbidities

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 2014 Apr 24

PMID 24756374

Citations 155

Authors

Miranda T Schram

Simone J S Sep

Carla J van der Kallen

Pieter C Dagnelie

Annemarie Koster

Nicolaas Schaper

Ronald M A Henry

Coen D A Stehouwer

Affiliations

Soon will be listed here.

Abstract

The Maastricht Study is an extensive phenotyping study that focuses on the etiology of type 2 diabetes (T2DM), its classic complications, and its emerging comorbidities. The study uses state-of-the-art imaging techniques and extensive biobanking to determine health status in a population-based cohort of 10,000 individuals that is enriched with T2DM individuals. Enrollment started in November 2010 and is anticipated to last 5-7 years. The Maastricht Study is expected to become one of the most extensive phenotyping studies in both the general population and T2DM participants world-wide. The Maastricht study will specifically focus on possible mechanisms that may explain why T2DM accelerates the development and progression of classic complications, such as cardiovascular disease, retinopathy, neuropathy and nephropathy and of emerging comorbidities, such as cognitive decline, depression, and gastrointestinal, musculoskeletal and respiratory diseases. In addition, it will also examine the association of these variables with quality of life and use of health care resources. This paper describes the rationale, overall study design, recruitment strategy and methods of basic measurements, and gives an overview of all measurements that are performed within The Maastricht Study.

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