Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Apr 24

PMID 24756092

Citations 13

Authors

Hee Nam Kim

Nan Young Kim

Li Yu

Yeo-Kyeoung Kim

Il-Kwon Lee

Deok-Hwan Yang

Je-Jung Lee

Min-Ho Shin

Kyeong-Soo Park

Jin-Su Choi

Hyeoung-Joon Kim

Affiliations

Soon will be listed here.

Abstract

The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)XRCC1 GA=0.80, p=0.02; OROGG1 GG=0.70, p=0.008; ORBRCA1 TT=0.71, p=0.048; ORWRN TT=0.68, p=0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR=1.25, p=0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR=0.74, p=0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR3435CT=1.50, p<0.0001; OR3435TT=1.43, p=0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients.

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References

Jamroziak K, Balcerczak E, Cebula B, Janus A, Mirowski M, Robak T . No influence of 3435C>T ABCB1 (MDR1) gene polymorphism on risk of adult acute myeloid leukemia and P-glycoprotein expression in blast cells. Ther Drug Monit. 2006; 28(5):707-11. DOI: 10.1097/01.ftd.0000245770.75097.3f. View

Heighway J, Margison G, Santibanez-Koref M . The alleles of the DNA repair gene O6-alkylguanine-DNA alkyltransferase are expressed at different levels in normal human lung tissue. Carcinogenesis. 2003; 24(10):1691-4. DOI: 10.1093/carcin/bgg124. View

Dogru-Abbasoglu S, Aykac-Toker G, Hanagasi H, Gurvit H, Emre M, Uysal M . The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease. Neurol Sci. 2007; 28(1):31-4. DOI: 10.1007/s10072-007-0744-x. View

Kim R, Leake B, Choo E, Dresser G, Kubba S, Schwarz U . Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther. 2001; 70(2):189-99. DOI: 10.1067/mcp.2001.117412. View

Huo X, Lu C, Huang X, Hu Z, Jin G, Ma H . Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. J Cancer Res Clin Oncol. 2009; 135(11):1569-75. DOI: 10.1007/s00432-009-0604-6. View

Perloff M, von Moltke L, Stormer E, Shader R, Greenblatt D . Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. Br J Pharmacol. 2001; 134(8):1601-8. PMC: 1572891. DOI: 10.1038/sj.bjp.0704399. View

Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati M . A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities. Diabetes. 2001; 50(8):1952-5. DOI: 10.2337/diabetes.50.8.1952. View

Hu J, Smith T, Miller M, Mohrenweiser H, Golden A, Case L . Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis. 2001; 22(6):917-22. DOI: 10.1093/carcin/22.6.917. View

Siegmund W, Ludwig K, Giessmann T, Dazert P, Schroeder E, Sperker B . The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. Clin Pharmacol Ther. 2002; 72(5):572-83. DOI: 10.1067/mcp.2002.127739. View

10.

Ambudkar S, Kimchi-Sarfaty C, Sauna Z, Gottesman M . P-glycoprotein: from genomics to mechanism. Oncogene. 2003; 22(47):7468-85. DOI: 10.1038/sj.onc.1206948. View

11.

Grulich A, Vajdic C, Cozen W . Altered immunity as a risk factor for non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007; 16(3):405-8. DOI: 10.1158/1055-9965.EPI-06-1070. View

12.

Chiu B, Weisenburger D, Hoar Zahm S, Cantor K, Gapstur S, Holmes F . Agricultural pesticide use, familial cancer, and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2004; 13(4):525-31. View

13.

Wang S, Davis S, Cerhan J, Hartge P, Severson R, Cozen W . Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis. 2006; 27(9):1828-34. DOI: 10.1093/carcin/bgl013. View

14.

Inoue R, Abe M, Nakabeppu Y, Sekiguchi M, Mori T, Suzuki T . Characterization of human polymorphic DNA repair methyltransferase. Pharmacogenetics. 2000; 10(1):59-66. DOI: 10.1097/00008571-200002000-00008. View

15.

Drescher S, Schaeffeler E, Hitzl M, Hofmann U, Schwab M, Brinkmann U . MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. Br J Clin Pharmacol. 2002; 53(5):526-34. PMC: 1874364. DOI: 10.1046/j.1365-2125.2002.01591.x. View

16.

Ameyaw M, Regateiro F, Li T, Liu X, Tariq M, Mobarek A . MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics. 2001; 11(3):217-21. DOI: 10.1097/00008571-200104000-00005. View

17.

Hoffmeyer S, Burk O, von Richter O, Arnold H, Brockmoller J, Johne A . Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000; 97(7):3473-8. PMC: 16264. DOI: 10.1073/pnas.97.7.3473. View

18.

De Roos A, Gold L, Wang S, Hartge P, Cerhan J, Cozen W . Metabolic gene variants and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomarkers Prev. 2006; 15(9):1647-53. DOI: 10.1158/1055-9965.EPI-06-0193. View

19.

Krzesniak M, Butkiewicz D, Samojedny A, Chorazy M, Rusin M . Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet. 2004; 68(Pt 4):300-12. DOI: 10.1046/j.1529-8817.2004.00079.x. View

20.

Stephens M, Smith N, Donnelly P . A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001; 68(4):978-89. PMC: 1275651. DOI: 10.1086/319501. View